AA in COMT's Val/Met variation, meaning Met/Met , or worrier , lower activity of the COMT enzyme. Since COMT enzyme's main function is the breakdown of dopamine, this leads to increased dopamine levels, advantages in attention tasks and motivation.
TT in rs4633, higher levels of the COMT protein and higher pain sensitivity - worrier
TT in COMT's rs4646312, slightly lower odds of schizophrenia
GG in COMT's rs6267, which is the typical for most humans and leads to slightly lower risk of Schizophrenia
AG in COMT's rs165599 variation, which means intermediate or average risk of Schizophrenia and Bipolar disorder.
AA in rs3027452, lowest transcription rates in the Central Nervous System - lower activity of MAOB. Tryptophan less effective for depression.
CC in MAOB's rs1799836; Lower odds of ADHD, Parkinson's, One study found higher odds of Schizophrenia
GG in MAOB's rs6324, typical (lower) ADHD risk, most common genotype
AA in MAOA's rs1800659, lower odds of post-surgical pain.
GG in MAOA's rs979605, decreased MAOA activity, worrier .
CC in MAOA's rs766117, higher odds of depression
Less D2 dopamine receptors 45.070 %.
Intermediate number of D2 dopamine receptors 39.437 %.
Higher number of D2 dopamine receptors 15.493 %.
AA or 2 derived No Go learner variants in DRD2's Pro319Pro variation, which causes a significant reduction in the number of D2 dopamine receptor sites in the brain, a reduction in the risk of schizophrenia, and an increased likelihood of No Go learning, which is the ability to withhold a response when it's not warranted.
CC in rs6279, lower odds of Schizophrenia
GG in DRD2's rs6275 variation, meaning less Dopamine D2 receptors and decreased risk of Schizophrenia.
CT in DRD2's rs2514218, slightly lower odds of Schizophrenia
GG genotype in rs4648317 of DRD2, which is the typical genotype for most humans, and leads to a slightly lower risk of Schizophrenia and nicotine dependence.
GG in Taq1 variation of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors, and to a slightly lower risk of ADHD and Alcoholism.
TT in DRD2's rs12363125, higher odds of Cocaine dependence - Risk haplotype for migraine
AG in DRD2's rs6589377, lower odds of neuroticism, but higher odds for nicotine dependence.
CC in rs1076560 of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors and better memory performance.
CC in rs5326 of DRD1, which is the typical for most humans and leads to a slightly lower risk of various mental health conditions.
GG in rs686 of Dopamine Receptor D1 gene, which is the typical and leads to lower likelyhood of autism.
CC in rs4532 of DRD1, a rare which is implicated in lower odds of Autism and tobacco addiction.
AA in rs265981 of DRD1, which is implicated in decreased risk of various mental health issues. This is most typical for Europeans.
TT in DRD1's rs4867798, part of a haplotype for reduced risk of schizophrenia according to 2014 study
AA in DRD1's rs265974, ~0.77x lower odds of substance use disorders.
GG in DRD1's rs265976, Patients with schizophrenia may have a better response when treated with clozapine as compared to patients with the GT genotype. Other genetic and clinical factors may also influence response to clozapine.
TT in rs6280 of DRD3, a typical associated with a slightly lower risk of OCD and intellectual disability.
AA in DRD3's rs167771 variation, mostly a Eurasian genotype , increases the risks of autism and autistic personality traits such as rigid behavior.
AA in DRD3's rs963468, higher odds of schizophrenia, uncommon genotype (doesn't play a role in the polygenic risk score calculation).
CC in rs11246226 of DRD4, which is a typical human and leads to decreased risk of Schizophrenia.
1 risk variant for mental retardation in DRD4's rs752306 (T)
AA in DRD4's rs936461, higher odds of schizophrenia but lower odds of eating disorder (OR=0.65).
Lower levels of 5-HT (Serotonin) 28.000 %.
Intermediate levels of 5-HT (Serotonin) 40.000 %.
Higher levels of 5-HT (Serotonin) 32.000 %.
CC in rs2129785, an incredibly rare that guaranteed long form 5-HTTLPR and decreased risk of depression.
CT in rs6311 of HTR2A, slightly increased risk of suicidal behavior and depression. Normal risk of sexual dysfunction when taking SSRI Antidepressants.
AG in rs6313 of HTR2A, Typical odds for suicidal ideation
GG in HTR2A's rs2070040, G allele is associated with lower resistance to stress, irritability, and agressive behavior.
GG in HTR2A's rs4142900, G allele is associated with higher antisocial behavior and impulsivity
GG in rs1545843, NOT associated with higher risk for major depression (risk allele is A)
AA in rs17144465, typical (lower) depression risk.
AG in ESRRG's rs2377360, one allele for higher odds of depression (G)
CT in rs364477, 1.69x odds of unipolar depression per C allele
TT in rs9834970 of TRANK1, below average odds of Bipolar disorder and Schizophrenia
TT in DISC1 rs1411771, somewhat lower odds of bipolar and schizophrenia (does not play a role in polygenic risk scores)
GG in rs75459873, no risk variants for psychosis in MIR378F. Very typical genotype.
AA in ADCY2's rs17826816, lower(typical) odds for bipolar disorder.
GG in rs11074889, slightly lower odds of ADHD - risk allele is A
Results Mental Health - Autism Only
Higher Odds of Autism 30.435 %.
Intermediate Odds of Autism34.783 %.
Lower Odds of Autism34.783 %.
CT in rs4307059, 1.19x risk of Autism
TT in rs10513025, typical , normal (higher) risk of autism.
TT in rs921451, More likely to smoke heavily if is a smoker.
TC, or heterozygous in rs1451371,average tendency to smoke heavily if is a smoker.
Results For Lactose Persistence
GG in MCM6's rs4988235 variation, which means this individual does not carry the European lactose persistence mutation.
TT in rs2322659 of LCT, likely lactose intolerant
Higher Odds of Lactose Intolerance: 44.828 %.
Intermediate Odds of Lactose Intolerance: 51.724 %.
Lower Odds of Lactose Intolerance: 3.448 %.
Results for OXTR - The Empathy Gene
Lower Empathy 27.273 %.
Average Empathy 45.455 %.
Higher Empathy 27.273 %.
TG in rs237885, one 'sociopath' variant and one 'empath' variant in OXTR.
TC in rs1042778 of OXTR, one 'sociopath' and one 'empath' allele, the empath allele is G
Results for Diabetes
CC in rs6679677; normal(lower) risk for Rheumatoid Arthritis and Type 1 Diabetes
AG in HLA's rs9272346, intermediate odds for Type 1 Diabetes.
TT in rs7202877, slight decrease in risk of Type 1 Diabetes.
TG in rs12255372, 1.3x increased type-2 diabetes risk
AG in rs17696736, slighly higher odds of type 1 Diabetes -risk allele is G
AG in rs35011184, higher odds of Type 2 diabetes and obesity.
GG in rs2476601 variation, which leads to lower risk of various autoimmune disorders and type 1 diabetes.
GG in rs17388568, normal (lower) odds of Type 1 Diabetes.
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes.
GG in rs7754840, which means this individual has two variants for lower odds of type 2 diabetes.
TC, or heterozygous in rs7903146, a associated with slight increase in the risk of type 2 diabetes.
TG in rs4402960, leading to slight increase in the risk of Type 2 Diabetes.
Results for Hemochromatosis
CC in HFE's His63Asp, which means this individual does not have any H63D variants and most likely doesn't have hemochromatosis.
AA in HFE's S65C variation, which means that this individual does not carry any risk variants for hemochromatosis.
Results for Alzheimers
CC in rs7412, which means no APOE2 alleles in Arg176Cys variation of the APOE gene and lower, or in other terms, normal odds of alzheimers disease.
GG in PLD3's rs145999145 variation, which means this individual has a lower risk of Alzheimers.
TT in rs669, which leads to slightly decreased risk of Alzheimers.
AG in TOMM40's rs2075650, higher odds of Alzheimer's disease.
CC in rs75932628, normal (Slightly lower) risk of Alzheimer's disease
CC in rs63750847, no variants for reduced risk of Alzheimer's disease. Normal (Higher) odds of Alzheimers
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS. Lower (typical) odds for narcolepsy as well.
No risk variants in HLA-DQA1; lower risk of MS
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
0 risk variants for MS in HLA-DRB1. Typical
AA in rs4959039, 2 (common) risk variants for MS.
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
TG in rs602633, 1 risk variant for Coronary Heart Disease (Odds ratio = 1.11 for every T allele). common genotype.
AA in rs700651, normal (lower) risk of aneurysm
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
TC, or heterozygous in rs1333040, average odds of brain aneurysm and heart attack, risk allele is T.
AA in rs9298506, normal (higher) risk of aneurysm.
TC in rs6475606, decreased risk for Coronary artery disease, risk allele is T.
TC in rs10757272, 1.30x increased risk for Coronary artery disease, risk allele is T.
CC in rs9315204, lower risk of aneurysm, common genotype.
AG in rs10757274, 1.2x increased risk for heart disease. Risk allele is G.
AG in rs2383206, 1.4x increased risk for heart disease. Risl allele is G.
AG in rs10757278, 1.3x risk for Heart Attack. Normal risk for Abdominal Aortic Aneurysm and Brain Aneurysm.
AG in rs5082, slightly reduced risk of heart disease (G allele reduces risk).
AA in rs17576, Higher odds of heart attack, lower odds of lung cancer.
Asthma + Epilepsy Panel
CT in rs7216389, Normal risk for Childhood Asthma. Risk varian is T
AA in rs1695, normal asthma risk in certain populations
CC in rs10496964, typical (higher) odds of epilepsy
AC in rs7587026, increased odds of epilepsy
AA in rs12059546, lower (typical) odds of epilepsy
GG in rs72823592, 1.3x odds of epilepsy
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness.
AA in rs7744813, which leads to a decrease in the risk of myopia.
TT in rs524952, which means an increased risk of myopia.
AC in rs4803455, one allele that protects from Myopia.
GG in RBFOX1's rs17648524, two alleles that protect against myopia.
Facial Morphology Panel
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
AA in rs6542787, 2 European EDAR alleles. Likely a European with European facial morphology
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
CC in rs892540, longer (typical) midface length
AG in PAX3s rs7559271, intermediate odds of protruding nasal bridge, A allele increases the odds of protruding nasal bridge
CC in rs938036, likely has mandibular third molar, lower odds of tooth agenesis (missing teeth)
AG in rs7702108, intermediate eyebrow thickness
Miscellaneous
(Don't voice this in video!!) CC in rs9332964, no micropenis.
CT in rs10784502, slightly increased cranial size and 1% higher IQ.
TT in rs28379706, lower IQ.
AA in rs324640, 8 points lower IQ than individuals with 'GG' .
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
TT in rs10427255, likely does not have photic sneeze reflex.
AG in SCN9A rs6746030 variation, 1 variant for increased pain sensitivity.
TT, no MYBPC2 mental retardation variants, likely healthy.
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer.
CT in rs6265, lower odds of obesity and major depressive disorder
Drug Responce
Risk of Heart Failure Due to Beta Blocker Medications is 1.153 times the average.
When treated with metoprolol
Relative to AA in rs1801252 & GG in rs1801253 Genotypes :
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : & GC in rs1801253
CC in CYP2C9's rs1799853, Good, no risk of altered warfarin metabolism or NSAID metabolism
GG in rs3745274, no increased risk when taking efavirenz for HIV treatment
AA in rs28399433, No Reduced CYP2A6 metabolism and no impaired nicotine metabolism - typical genotype
AT in rs1801272, Reduced CYP2A6 metabolism; impaired nicotine metabolism?, risk variant is T ⚠
CC in CYP1A2's rs28399424, Good, normal CYP1A2 activity
CC in CYP1A2's rs12720461, Good, normal CYP1A2 activity
GG in rs4986893, no CYP2C19*3 allele (Good)
GG in CYP2D6's rs1065852, NOT carrier for CYP2D6 decreased or non-functioning variants (good)
TT in rs4363657, lower(typical) myopathy risk for statin users
AA in rs637644, lower odds of hair loss from chemotherapy.
AA in rs594206, highest odds of hair loss from chemotherapy. ⚠
GG in DRD1's rs265976, Patients with schizophrenia may have a better response when treated with clozapine as compared to patients with the GT genotype. Other genetic and clinical factors may also influence response to clozapine.
AG in rs2273697, Adverse reaction more likely to carbamazepine in epileptic patients ⚠
CT in rs2298383, one allele for increased anxiety in response to caffeine. ⚠
AC in rs762551, Carrier of one CYP1A2*1F allele; Normal (faster) metabolism of caffeine ⚠
CC in rs3892097, extensive CYP2D6 metabolizer
CC in rs1467558, lower (normal) risk of liver toxicity from acetominophen/tylenol/APAP
CC in rs10156191 of AOC1, normal (increased) DOA activity, normal genotype. Tolerates NSAIDs.
TT in rs12476047. Lower than average odds of parkinson's symptoms when treated with antipsychotics
TT in rs5092, more likely to gain weight if taking olanzapine. ⚠
TC, or heterozygous in rs4765623, more likely to gain weight if taking olanzapine. ⚠
CC in rs3813929, higher odds of weight gain if taking olanzapine. ⚠
CC in rs518147, less weight gain if taking olanzapine.
TT in AKT1's rs2494732, lower odds of Cannabis induced psychosis.
AG in rs2241802, average odds of methamphatamine induced psychosis. ⚠
CC in rs135745, higher susceptibility to methamphetamine induced psychosis. ⚠
AA in rs12591257, no protection from Methamphetamine induced psychosis ⚠
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation.
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism.
CC in TYR's rs104894313, Not Carrier of an oculocutaneous Albinism Type 1B mutation.
CC in rs987525, which leads to decreased risk of cleft lip and palate.
Familiar Mediterranean Fever Panel
0 risk variants in rs3743930.
0 risk variants in rs11466023
0 risk variants in rs104895081
0 risk variants in rs104895157
0 risk variants in rs11466024
0 risk variants in rs11466026
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
AG in MTHFR's rs1801133, 65% efficiency in processing folic acid. Slightly higher than average odds for a variety of illnesses from autism to coronary heart disease.
TT in MTHFR's rs1801131, most common genotype , lower odds of various health issues.
AA in rs17367504, common , average (higher) blood pressure.
CC in rs2274976, Good, lower odds of neural tube defects
GG in rs2066470, typical genotype.
Cancers Panel
Higher Odds of Epithelial Cancers: 2.273 %.
Intermediate Odds of Epithelial Cancers: 38.636 %.
Lower Odds of Epithelial Cancers: 59.091 %.
Glioma
TT in 8q24 rs4295627, lower odds of glioma development
AA in EGFR's rs11979158, very slight increase in the odds of glioma.
CC in EGFR's rs2252586, lower (average) odds of glioma
GG in rs498872, slightly below average odds of glioma (normal).
AA in rs4977756, lower odds of glioma
GG in rs6010620, 1.4x higher risk for glioma development; but this is the common allele. 1.4x higher risk for atopic dermatitis in Han Chinese
Prostate
AG in rs1859962, average odds of prostate cancer - risk allele is G.
CC in HOXB13's rs138213197, normal (lower) risk of prostate cancer in men
CC in 8q24 rs16901979, no risk alleles for prostate cancer (Good)
TT in 8q24 rs6983267, lower risk of prostate cancer
CC in 8q24 rs1447295, no risk alleles for prostate cancer (Good)
Breast - BRCA
0 risk variants in Q356R of BRCA1
0 risk variants in BRCA1's D693N.
0 risk variants in S1140G of BRCA1
0 risk variants in K1183R of BRCA1
0 risk variants in S1613G of BRCA1
0 risk variants in N289H of BRCA2.
0 risk variants in N372H of BRCA2
CC in rs1042522 of TP53. Uncommon genotype. Live 3 years longer. Chemotherapy is more effective.
TT in rs1801155, average (lower) risk of colon cancer
0 risk variants in S707P
AG in Estrogen Receptor 1 Gene's -351A>G variation. Women have normal (lower) risk of Endometriosis, 0.75x lower risk of Endometrial Cancer, and normal (higher) risk of cognitive impairment.
Testicular - KITLG
AG in rs995030, 2 times Reduced risk of testicular cancer.
AG in rs4474514, 3x increased testicular cancer risk for men
Leukemia Panel
AG in rs1800566, 1 NQO1*2 allele (1 risk variants for leukemia).
GT in rs4132601, somewhat (1.7x) increased risk for acute lymphoblastic leukemia.
GT in rs7089424, somewhat (~2x) increased risk for acute lymphoblastic leukemia.
AG in rs2239633, average odds of leukemia.
Rare diseases/traits Panel
GG in rs75801644, 0 risk variants for endometriosis.
AA in F9 rs137852229, not a Carrier of a Hemophilia B mutation - 0 risk variants
TT in rs9540294, average (lower) odds of Recalcitrant atopic dermatitis
CC in rs41280169, 0 risk variants for panic disorder (very common genotype)
GG in rs79919349, 0 risk variants for panic disorder (very common genotype).
No predisposition to hemoglobin E disease, TT in rs2071348
CC in rs119478057, no predidposition to Hypercarotenemia and vitamin a deficiency
GG in rs387906725, no Lesch-nyhan syndrome.
TT in rs121434622, no Fragile X syndrome
GG in rs61816761, normal (no dermatitis)
GG in rs74315329, not a carrier for Glaucoma (primary open-angle).
AG in rs893818, average odds of Exfoliation glaucoma.
AG in rs3825942, possibly lower glaucoma risk.
AA in rs16863657, lower odds of neural tube defects, typical genotype.
GG in rs80338794, not a Finnish major Salla disease mutation carrier - 0 risk variants.
Found 0 risk variants for Holoprosencephaly in GLI2. Very typical/common genotype
GG in rs34536443, typical (lower) odds of tuberculosis infection, common genotype
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
TG in rs10033464, 1.28x increased risk of Atrial Fibrillation and cardioembolic stroke.
AA in rs660895, decreased risk of rheumatoid arthritis. Slightly decreased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
AC in rs7743761, 4.6x increased risk of Ankylosing Spondylitis. Risk allele is A.
CT in rs6457617, significantly increased risk for RA and Systemic sclerosis, risk allele is T
GG in rs11090865, common in clinvar, no risk variants for deafness.
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
CT in rs4794067; 2.1x risk for Aspirin Induced Asthma. But possibly lower risk of intractible Grave's disease.
CC in rs10156191 of AOC1, normal (increased) DOA activity, normal genotype. Tolerates NSAIDs.
CC in rs104894635, no risk variants for Sanfilippo syndrome
CC in rs1800546, normal.
AA in rs3764147, 0 risk variants for leprosy.
GG in rs11606250, most common , but higher risk for certain autoimmune diseases.
Celiac Disease Panel
average, no HLA-DRB1*0301 alleles, normal risk of celiac disease and lupus.
no HLA-DQ8 haplotype, normal (lower) risk of Celiac disease.
1 risk variant in CCR3
No risk variants in IL18R1
AA in rs13119723, lower (normal) risk for celiac disease. 0 risk variants
1 risk variant in R262W
Allergies Panel
GG in rs62623409, typical odds of allergic sensitivity
AA in rs2367563, nickel likely causes an allergic skin reaction.
TT in rs2155219, 2 alleles for higher odds of allergies. Odds Ratio for every T allele = 1.18
CC in rs17513503, lower odds of allergies; common
GT in rs7192, somewhat (1.7x) increased risk of developing a peanut allergy. Risk variant is T.
TC, or heterozygous in rs9275596, 1.7x (relative to TT ) increased risk for developing a peanut allergy, risk allele is C.
Androgen Receptor Gene (AR) Panel
CC in rs137852591, very typical ; no Androgen insensitivity.
GG in rs9332969, normal , no Reifenstein syndrome.
GG in rs9332971, normal , no Reifenstein syndrome.
Crohn's Disease Panel
CC in NOD2's Arg702Trp. Typical (lower) risk for Crohn's disease.
Canavan Syndrome Panel
GG in rs104894553, 0 risk variants.
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
1 protective variant in HLA-C's rs9264942 (Good), atypical genotype. 60% reduction in HIV viral load
common (Good), no risk variants in rs2395029 (TT )
AG in rs2572886, 1 risk variant for increased susceptibility to AIDs and higher HIV viral load (Bad, uncommon).
HLA Gene Panel
The HLA genes are located on chromosome 6 in humans and encode proteins called human leukocyte antigens (HLAs). These proteins play a vital role in immune responses by presenting antigens to immune cells, specifically T cells. There are two main classes of HLA proteins: class I and class II.
The HLA system plays a critical role in several medical contexts, including organ transplantation, where matching HLA types between donor and recipient is crucial to minimize the risk of rejection. Additionally, HLA genes are associated with susceptibility to certain autoimmune diseases, infectious diseases, and drug hypersensitivity reactions, making them important targets for medical research and personalized medicine.
Here is a list of conditions affected by, and predicted by this Panel: Rheumatoid arthritis, systemic lupus erythematosus (SLE), type 1 diabetes mellitus, multiple sclerosis (MS), Sjögren's syndrome, inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis, celiac disease, ankylosing spondylitis, systemic sclerosis, psoriasis, Graves' disease, Hashimoto's thyroiditis, Addison's disease, vitiligo, myasthenia gravis, primary biliary cholangitis, autoimmune hepatitis Susceptibility or severity of certain viral infections (e.g., HIV, hepatitis B and C), some bacterial infections (e.g., leprosy, tuberculosis) Food allergies (e.g., peanut allergy, milk allergy), Allergic rhinitis (hay fever), Atopic dermatitis (eczema), Asthma Allograft rejection, Preeclampsia, and Certain neurological disorders (e.g., narcolepsy)
Highest odds of Autoimmune Disease 7.609 %
Intermediate (Slightly higher) Odds of Autoimmune Disease 45.652 %
Lower Odds of Autoimmune Disease 46.739 %.
MTRR Gene Panel
AG in rs1801394, slightly higher odds for meningomas and neural tube defects. 1 risk allele for disorders of Intracellular Cobalamin Metabolism
CC in rs10380, lower odds of pancratic cancer; 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AA in rs162036, no risk variants for spina bifida & Disorders of Intracellular Cobalamin Metabolism.
CC in rs2287780, no risk variants for Disorders of Intracellular Cobalamin Metabolism
TT in rs2303080, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AG in rs1802059, 1 risk allele for disorders of Intracellular Cobalamin Metabolism
CC in CBS's rs234709, slightly increased homocysteine levels
Predisposed to higher levels of Plasma homocysteine, CC in rs6586282
Predisposed to intermediate levels of Plasma homocysteine, CT in rs2851391, T allele leads to lower levels
homocystinuria Panel
We found Risk variants in : rs1789953(1) and a total of 1 risk variants for homocystinuria in CBS gene out of 10 variants identified in your file in total.
Elevated homocysteine levels 24.000 %
Intermediate homocysteine levels 56.000 %
Lower homocysteine levels 20.000 %.
Thyroid Cancer Panel
GG in rs965513, normal(lower thyroid cancer risk).
CT in rs944289, 1.3x increased thyroid cancer risk
CC in rs116909374, typical(lower) odds of thyroid cancer
CC in rs966423, Possible elevated thyroid cancer risk
CC in rs2439302, lower odds of thyroid cancer
Muscular Dystrophy Myopathies
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk alleles in rs2296949
0 risk variants in rs28937900
0 risk variants in rs193922094
Found : 0 risk variants for adrenoleukodystrophy out of 42 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 4
0 risk variants in OPN1MW out of 0
1 risk variants in OPN1SW out of 4
FTO Gene Panel
Higher Odds of Obesity 19.048 %.
Intermediate Odds of Obesity47.619 %.
Lower Odds of Obesity33.333 %.
1 risk allele (G) for obesity in rs9930506, slightly higher than average risk of obesity
Heterozygous in rs1421085, 1.3x higher risk of obesity
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
Within PFKP Gene - also implicated in Obesity
GG in rs6602024, lower BMI
Others also implicated in Obesity
AA in rs4994, typical genotype - lower odds of obesity.
TT in rs6232, lower risk of obesity and insulin sensitivity
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
AA in rs1431318, around 7% increase in the risk of syncope.
Used 1 snps in the following prediction
Syncope risk is 1.080 times the average
Bio Traits Panel
AA in MTR's rs1805087, decreased MTR activity and increased homocysteine levels (doesn't contribute to homocysteine panel score)
CT in rs174528, intermediate levels of omega 3 fatty acid, intermediate levels of docosahexaenoic acid - T allele increases levels
TT in rs174547, higher resting heart rate, higher omega-6 and omega-3 levels
ACE I/D genotype, increased ACE activity - healthier, reduced odds of hypertension and a range of other issues.
CC in rs1544410, Decreased risk of low bone mineral density disorders
GG in rs1051730, Smokes normal (lower) number of cigarettes if a smoker, reduced odds of lung cancer.
rs5443 (CC) lower risk of hypertension and obesity, lower responce to viagra, less weight gain when treated with clozapine
GG in CDH4's rs16985493, typical genotype associated with lower/average risk for migraine.
TT in rs185819, ~30mm shorter
CC in rs1042725, ~0.8cm taller height relative to TT genotype
CC in rs6060369, ~0.88cm taller height relative to TT genotype
AA in rs10946808, taller.
GG in rs1800795, more IL6, significantly associated with type-2 diabetes (odds ratio 1.51)
AA in rs1380703, longer (typical) sleep duration
AG in rs66800491, higher odds of motion sickness (This is the variation with highest impact for motion sickness)
CC in rs2148710, lower predisposition to anger
Wet earwax. Normal (smellier) body odour. Normal colostrum. Typical for non-East Asians. CC in rs17822931
One copy of "hunter-gather" CLTCL1 gene variant + one "farmer" variant. Intermediate ability to process carbs and sugars. Farmer allele is C
CC in rs307377, common in complete genomics - no extraordinary tasting ability
AA in rs662799, normal (Lower odds of heart attack and obesity)
CT in rs27072, Lower risk of alcohol withdrawal seizures, and perhaps lower odds of ADHD.
GG in rs4481887, least likely to be able to smell asparagus metabolites in urine
AA in rs6591536, less able to detect β-ionone (floral) fragrance
GG in rs11800854, higher (typical) odds of periodontitis
GG in rs234706, no alleles for reduced odds of cleft palate
Age Related Macular Degeneration
GG in rs547154, no increased protection from Age-related maculopathy, most typical genotype.
AC in rs1061147 , Normal 0.97x risk for Age Related Macular Degeneration. (risk allele is A)
GG in rs11200638, normal risk of age related macular degeneration
GG in rs2230199, normal (reduced) risk for AMD
CG in rs380390, higher odds of AMD, risk allele is C
CC in rs3793917, lower (typical) odds for AMD
AG in rs800292, increased odds of Age-related macular degeneration (MTAG)
Cataracts Panel
GG in rs62621812, typical genotype, lower (typical) risk for cataracts.
AG in rs1929494, ~1.1x risk for cataracts
Vitamins and Levels
TT in rs2282679 of GC gene, normal levels of Vitamin D.
AC in rs7041, one allele for reduced vit D levels (A), intermediate odds for COPD if you smoke - average levels of vitamin D ⚠
TT in rs12785878, lower levels of Vitamin D. ⚠
GG in rs10741657, tend to have lower vitamin D levels ⚠
TT in rs7129781, decreased odds of Vitamin D insufficiency
CT in rs6544713, slightly higher LDL cholesterol ⚠
