GG in COMT's Val/Met variation, meaning Val/Val , or warrior , higher activity of the COMT enzyme and quicker breakdown of dopamine. Individuals with this have advantages in stress resilience but disadvantages in attention tasks
CC in rs4633, higher expression levels of the COMT protein and protection from endometrial cancer, lower pain sensitivity - warrior
CT in COMT's rs4646312, slightly higher odds of schizophrenia (Odds ratio 1.25 per risk allele, pval 8 x 10-6). Risk allele is C
GG in COMT's rs6267, which is the typical genotype for most humans and leads to slightly lower risk of Schizophrenia
GG in COMT's rs165599 variation, which typically results in higher risk of Schizophrenia and Bipolar disorder
AA in rs3027452, lowest transcription rates in the Central Nervous System - lower activity of MAOB. Tryptophan less effective for depression
CC in MAOB's rs1799836; Lower odds of ADHD, Parkinson's, One study found higher odds of Schizophrenia
GG in MAOB's rs6324, typical (lower) ADHD risk, most common genotype
TT in MAOA's rs6323, leading to lower activity of the MAOA enzyme and slower breakdown of dopamine, thus higher dopamine levels and certain advantages in attention tasks
AA in MAOA's rs1800659, lower odds of post-surgical pain
GG in MAOA's rs979605, decreased MAOA activity, worrier
CC in MAOA's rs766117, higher odds of depression
Less D2 dopamine receptors 39.394 %.
Intermediate number of D2 dopamine receptors 39.394 %.
Higher number of D2 dopamine receptors 21.212 %.
CC in DRD2's rs2514218, higher odds of Schizophrenia
GG genotype in rs4648317 of DRD2, which is the typical genotype for most humans, and leads to a slightly lower risk of Schizophrenia and nicotine dependence
AG in Taq1 variation of DRD2, which is implicated in a slightly decreased number of Dopamine D2 receptor sites in the brain and a slightly increased likelihood of Alcoholism, Parkinson's, ADHD
CC in DRD2's rs12363125, lower odds of cocaine dependence and migraine, higher D2 receptor availability
AA in DRD2's rs6589377, higher (typical) odds of neuroticism, but lower odds for nicotine dependence
AC in rs1076560 of DRD2, which is implicated in a slightly decreased number of Dopamine D2 receptor sites in the brain and a slightly increased likelihood of Alcoholism
TC, or heterozygous in rs5326 of DRD1, which is implicated in slightly higher odds of bipolar disorder andd schizophrenia
AA in rs686 of Dopamine Receptor D1 gene, which leads to a higher likelihood of Autism
TT in rs4532 of DRD1, a typical associated with slightly higher odds of Autism and tobacco addiction
GG in rs265981 of DRD1, which is the typical for most humans, and leads to a slightly higher risk of Schizophrenia and nicotine dependence
GG in DRD1's rs265974, ~1.29x odds of substance use disorders
TT in DRD1's rs265976, Patients with schizophrenia may have a better response when treated with clozapine as compared to patients with the GT genotype. Other genetic and clinical factors may also influence response to clozapine
TC, or heterozygous in rs6280 of DRD3, which is implicated in slightly higher risk of OCD and intellectual disability
AG in DRD3's rs167771 variation, mostly a Eurasian genotype ,slight increase in the risks of autism and autistic personality traits such as rigid behavior
AG in DRD3's rs963468, higher odds of schizophrenia, risk allele is A (doesn't play a role in the polygenic risk score calculation)
CC in rs11246226 of DRD4, which is a typical human and leads to decreased risk of Schizophrenia
No risk variants for mental retardation in DRD4's rs752306 (CC)
TT in DRD5's rs6283. Lower odds of ADHD; mechanism of action is not exactly known
Lower levels of 5-HT (Serotonin) 33.333 %.
Intermediate levels of 5-HT (Serotonin) 40.741 %.
Higher levels of 5-HT (Serotonin) 25.926 %.
TT in rs2129785, a typical for most humans. The implications of this is that this individual does not have long form 5-HTTLPR and does not have a decrease in the risk of depression
CC in rs6311 of HTR2A, robustly increased risk of suicidal behavior and depression. 3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants
GG in rs6313 of HTR2A, lower odds for suicidal ideation
TT in HTR2A's rs4142900, G allele is associated with higher antisocial behavior and impulsivity
AG in rs17144465, one rare allele for increased odds of depression (G)
AA in ESRRG's rs2377360, lower odds of depression
TT in rs364477, reduced odds of unipolar depression
TT in rs9834970 of TRANK1, below average odds of Bipolar disorder and Schizophrenia
CT in DISC1 rs1411771, somewhat higher odds of bipolar disorder and schizophrenia (does not play a role in polygenic risk scores)
AA in ADCY2's rs17826816, lower(typical) odds for bipolar disorder
CC in rs267606861, common in clinvar, no tourette
GG in rs11074889, slightly lower odds of ADHD - risk allele is A
Results Mental Health - Autism Only
Higher Odds of Autism 54.839 %.
Intermediate Odds of Autism38.710 %.
Lower Odds of Autism6.452 %.
TT in rs4307059, 1.42x risk of Autism, worse cell adhesion in neurons
TT in rs10513025, typical , normal (higher) risk of autism
AC in rs1804197, uncommon , Increased risk of familial colorectal cancer and Asperger's syndrome (risk allele is A)
AA in rs2217262, typical genotype. Average (higher) risk of autism
GG in rs930707, typical (higher) Indoleacetate levels. Indoleacetate is a tryptophan derivative and lower levels of indoleacetate are linked with depressive symptoms
Results For lactase persistence
AG in MCM6's rs4988235 variation, which means this individual is heterozygous for the European lactase persistence mutation and is probably not lactose intolerant
TC in MCM6's rs182549, This Individual has 1 derived variant for European lactase persistence and is likely not lactose intolerant
AA in rs41380347, NOT carrier of the lactase persistence allele also known as "-13915*G", common in Arab populations
CT in rs2322659 of LCT, likely lactase persistent - C allele is not exclusive to Europeans
Higher Odds of Lactose Intolerance: 4.348 %.
Intermediate Odds of Lactose Intolerance: 43.478 %.
Lower Odds of Lactose Intolerance: 52.174 %.
Results for OXTR - The Empathy Gene
Lower Empathy 21.053 %.
Average Empathy 36.842 %.
Higher Empathy 42.105 %.
GG in OXTR's rs53576 variation, which means this individual has 2 variants for higher levels of empathy at this variation
TT in rs237885, two 'sociopath' variants in OXTR
GG in rs1042778 of OXTR, higher oxytocin and empathy
AG in OXTR's rs7632287 variation, which means this individual has 1 variant for higher OXTR expression and increased levels of empathy
GG in OXTR's rs237897, two variants for higher levels of empathy in this OXTR variation. Most likely not East Asian
Results for Diabetes
CC in rs6679677; normal(lower) risk for Rheumatoid Arthritis and Type 1 Diabetes
TT in rs7202877, slight decrease in risk of Type 1 Diabetes
GG in rs12255372, decreased risk of Type 2 Diabetes
AG in rs17696736, slightly higher odds of type 1 Diabetes -risk allele is G
GG in rs2476601 variation, which leads to lower risk of various autoimmune disorders and type 1 diabetes
AG in rs17388568, 1 risk variant (A), 1.3x risk of type-1 diabetes
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes
GG in rs7754840, which means this individual has two variants for lower odds of type 2 diabetes
CC in rs7903146, a associated with lower risk of type 2 diabetes
TG in rs4402960, leading to slight increase in the risk of Type 2 Diabetes
Results for Hemochromatosis
GG in HFE's Cys282Tyr variation, which means this individual is not a carrier for the C282Y hemochromatosis mutation
CC in HFE's His63Asp, which means this individual does not have any H63D variants and most likely doesn't have hemochromatosis
AA in HFE's S65C variation, which means that this individual does not carry any risk variants for hemochromatosis
Results for Alzheimer's
CC in rs7412, which means no APOE2 alleles in Arg176Cys variation of the APOE gene and lower, or in other terms, normal odds of Alzheimer's disease
TT in rs669, which leads to slightly decreased risk of Alzheimer's
AG in TOMM40's rs2075650, higher odds of Alzheimer's disease
CC in rs75932628, normal (Slightly lower) risk of Alzheimer's disease
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS. Lower (typical) odds for narcolepsy as well
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS
0 risk variants for MS in HLA-DRB1. Typical
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
GG in rs602633, 0 risk variants for Coronary Heart Disease (Odds ratio = 1.11 for every T allele). common genotype
GG in rs700651, ~20% higher risk of brain aneurysm, risk allele is G
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
TT in rs1333040, higher odds of brain aneurysm and heart attack
TT in rs6475606, increased risk for Coronary artery disease
TT in rs10757272, 1.54x increased risk for Coronary artery disease
TC in rs9315204, slightly higher risk of aneurysm, uncommon genotype
GG in rs10757274, 1.3x increased risk for heart disease
GG in rs2383206, 1.7x increased risk for heart disease
GG in rs10757278, 1.6x risk for Heart Attack; 1.3x risk for Abdominal Aortic Aneurysm and Brain Aneurysm
CC in rs1800787, not a carrier of risk variants for carotid artery disease (T)
AG in rs5082, slightly reduced risk of heart disease (G allele reduces risk)
AG in rs17576, average odds of heart attack and lung cancer
Asthma + Epilepsy Panel
CC in rs7216389, 0.69x lower risk of Childhood Asthma
AG in rs1695, mixed evidence showing either increased or decreased risk of asthma
TT in rs10030601, below average odds of epilepsy
CT in rs10496964, reduced odds of epilepsy (x0.8)
CC in rs7587026; decreased (typical) odds of epilepsy
AA in rs12059546, lower (typical) odds of epilepsy
AA in rs72823592, lower (typical) odds of epilepsy
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness
AA in rs7744813, which leads to a decrease in the risk of myopia
AC in rs4803455, one allele that protects from Myopia
GG in RBFOX1's rs17648524, two alleles that protect against myopia.
CC in rs3138142, higher odds of myopia
Facial Morphology Panel
AA genotype in EDAR's rs3827760, Likely no shovel-shaped incisors and not East Asian in ancestry
AA in rs6542787, 2 European EDAR alleles. Likely a European with European facial morphology
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans
CT in rs892540, slightly shorter midface length
AG in PAX3s rs7559271, intermediate odds of protruding nasal bridge, A allele increases the odds of protruding nasal bridge
Likely higher nasolabial angle (nose pointing up) based on DCHS2 genotype
CC in rs938036, likely has mandibular third molar, lower odds of tooth agenesis (missing teeth)
AG in rs7702108, intermediate eyebrow thickness
Miscellaneous
CC in rs9332964, no micropenis
GG in SRD5A2's rs104893667 variation, which means this individual does not have micropenis
CT in rs10784502, slightly increased cranial size and 1% higher IQ
CT in rs28379706, slightly higher IQ
GG in rs324640, 8 points higher IQ than individuals with 'AA'
CC in rs1815739, Better performing muscles. Likely sprinter
TT , No 'fat gene' variants in FTO's rs9939609
TT in rs10427255, likely does not have photic sneeze reflex
AA genotype in EDAR's rs3827760, Likely no shovel-shaped incisors and not East Asian in ancestry
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer
CT in rs6265, lower odds of obesity and major depressive disorder
Drug response
Risk of Heart Failure Due to Beta Blocker Medications is 1.153 times the average.
When treated with metoprolol
Relative to AA in rs1801252 & GG in rs1801253 Genotypes :
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : & GC in rs1801253
CC in EGFR's rs2293347, among NSCLC patients, better Gefitinib response; common
DD in rs67666821, common in complete genomics
AA in CYP2C9's rs1057910, normal; no effect on warfarin metabolism
CC in CYP2C9's rs1799853, Good, no risk of altered warfarin metabolism or NSAID metabolism
TG in rs3745274, If efavirenz is ever prescribed for you, perhaps lower doses may be advisable - risk allele is T ⚠
AG in rs2279343, perhaps lower doses of efavirenz for treating HIV may be recommended. ⚠
AC in rs28399433, Reduced CYP2A6 metabolism; impaired nicotine metabolism? Risk variant is C ⚠
AA in rs1801272, no reduced CYP2A6 metabolism, no impaired nicotine metabolism, typical genotype
CC in CYP1A2's rs12720461, Good, normal CYP1A2 activity
GG in rs4986893, no CYP2C19*3 allele (Good)
AG in rs4244285, poorer metabolizer of several popular medicines including mephenytoin, some antidepressants, Plavix; patients prescribed Plavix get less benefit, and have higher risk for adverse cardiovascular events ⚠
TT in rs4363657, lower(typical) myopathy risk for statin users
GG in rs637644, higher odds of hair loss from chemotherapy. ⚠
AA in rs594206, highest odds of hair loss from chemotherapy. ⚠
TT in DRD1's rs265976, Patients with schizophrenia may have a better response when treated with clozapine as compared to patients with the GT genotype. Other genetic and clinical factors may also influence response to clozapine
UGT1A1 D/D on Ancestry - normal
GG in rs2273697, Adverse reaction less likely to carbamazepine in epileptic patients
CT in rs2298383, one allele for increased anxiety in response to caffeine. ⚠
AC in rs762551, Carrier of one CYP1A2*1F allele; Normal (faster) metabolism of caffeine ⚠
CT in rs1467558, higher risk of liver toxicity from acetominophen/tylenol/APAP ⚠
CT in rs10156191 of AOC1, decreased DOA activity, may not tolerate NSAIDs so well. The risk allele is T. This is a fairly common genotype. ⚠
CT in rs12476047. Much higher odds of Parkinson's symptoms when treated with antipsychotics, risk allele is C ⚠
TT in rs5092, more likely to gain weight if taking olanzapine. ⚠
TC, or heterozygous in rs4765623, more likely to gain weight if taking olanzapine. ⚠
CC in rs3813929, higher odds of weight gain if taking olanzapine. ⚠
AG in rs2241802, average odds of methamphatamine induced psychosis. ⚠
CC in rs135745, higher susceptibility to methamphetamine induced psychosis. ⚠
AA in rs12591257, no protection from Methamphetamine induced psychosis ⚠
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation
AA in TYR's rs28940881 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations
AA in TYR's rs28940878 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism
CC in TYRP1's rs104894130, which means this individual lacks variants for Oculocutaneous albinism type 3, and is not albino
CC in rs987525, which leads to decreased risk of cleft lip and palate
Familiar Mediterranean Fever Panel
0 risk variants in rs104895094
0 risk variants in rs3743930.
0 risk variants in rs11466023
0 risk variants in rs61752717
0 risk variants in rs28940579
0 risk variants in rs28940578
0 risk variants in rs61732874
0 risk variants in rs104895083
0 risk variants in rs104895097
0 risk variants in rs104895085
0 risk variants in rs104895081
0 risk variants in rs11466024
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
AA in MTHFR's rs1801133, 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levels. Higher odds for a variety of illnesses from autism to coronary heart disease
TT in MTHFR's rs1801131, most common genotype , lower odds of various health issues
AA in rs17367504, common , average (higher) blood pressure
CC in rs2274976, Good, lower odds of neural tube defects
GG in rs2066470, typical genotype
Cancers Panel
Highest Odds of Epithelial Cancers: 17.500 %.
Intermediate (slightly higher) Odds of Epithelial Cancers: 42.500 %.
Lower (typical) Odds of Epithelial Cancers: 40.000 %.
Glioma
AA in 8q24 rs55705857, normal (lower risk of glioma)
TG in 8q24 rs4295627, 1.36x higher risk for glioma development, risk variant is G
AA in EGFR's rs11979158, very slight increase in the odds of glioma
CT in EGFR's rs2252586, slightly higher odds of glioma, risk allele is T
GG in rs498872, slightly below average odds of glioma (normal)
AA in rs4977756, lower odds of glioma
AG in rs6010620, 1.2x higher risk for glioma development, 1.17x higher risk for atopic dermatitis in Han Chinese
Prostate
GG in rs1859962, higher odds of prostate cancer
CC in HOXB13's rs138213197, normal (lower) risk of prostate cancer in men
No rare variant for prostate cancer
AA in 8q24's rs138042437, lower (typical) odds of prostate cancer
GG in 8q24 rs6983267, 1.6x increased risk for prostate cancer; also other cancers
CC in 8q24 rs1447295, no risk alleles for prostate cancer (Good)
Breast - BRCA
0 risk variants in Q356R of BRCA1
1 risk variant in BRCA1's D693N
0 risk variants in S1140G of BRCA1
2 risk variants in K1183R of BRCA1
2 risk variants in S1613G of BRCA1
0 risk variants in N289H of BRCA2
0 risk variants in N372H of BRCA2
CC in rs1042522 of TP53. Uncommon genotype. Live 3 years longer. Chemotherapy is more effective
TT in rs1801155, average (lower) risk of colon cancer
0 risk variants in S707P
Testicular - KITLG
AG in rs995030, 2 times Reduced risk of testicular cancer
AG in rs4474514, 3x increased testicular cancer risk for men
Other Cancers
AA in AURKA's rs2273535, slightly lower (normal) odds for various cancers
GG in EGFR rs763317, lower(typical) risk of lung cancer
CT in rs710521, Normal risk of developing bladder cancer. Risk allele is T
CC in rs798766, Lower (normal) risk of developing urinary bladder cancer
GG in rs1800629, good, lower odds of lymphoma among a variety of other illnesses
TNF Risk Variants for Lymphoma: 0 Out of 6 variants found in file in total
No risk variants found in file
The presence of any risk variants is a concern
Thyroid Cancer
AG in rs965513, 1.77x increased thyroid cancer risk
CC in rs944289, lower thyroid cancer risk
CC in rs116909374, typical(lower) odds of thyroid cancer
CT in rs966423, one allele for Possible elevated thyroid cancer risk
GG in rs2439302, higher than average odds for thyroid cancer
Leukemia Panel
GG in rs1800566, 0 NQO1*2 alleles (0 risk variants for leukemia)
TT in rs4132601, common -> lower risk of leukemia
AG in rs2239633, average odds of leukemia
Rare diseases/traits Panel
No rare variant for prostate cancer
AA in F9 rs137852229, not a Carrier of a Hemophilia B mutation - 0 risk variants
TT in rs9540294, average (lower) odds of Recalcitrant atopic dermatitis
No predisposition to hemoglobin E disease, TT in rs2071348
CC in rs119478057, no predidposition to Hypercarotenemia and vitamin a deficiency
GG in rs387906725, no Lesch-nyhan syndrome
GG in rs28942100, not a Carrier of a alkaptonuria mutation - 0 risk variants
TT in rs121434622, no Fragile X syndrome
CC in rs199473058, no Brugada Syndrome
GG in rs121434528, 0 risk alleles for Thoracic aortic aneurysm and dissection
GG in rs61816761, normal (no dermatitis)
GG in rs74315329, not a carrier for Glaucoma (primary open-angle)
AG in rs893818, average odds of Exfoliation glaucoma
CC in rs28936694, no Primary open-angle glaucoma
normal, no risk variants for cystic fibrosis in F-508
AA in rs16863657, lower odds of neural tube defects, typical genotype
CC in rs6445; no congenital adrenal hyperplasia
GG in rs80338794, not a Finnish major Salla disease mutation carrier - 0 risk variants
0 variants for Ehlers-Danlos syndrome; CC in rs28937869
Found 0 risk variants for Holoprosencephaly in GLI2. Very typical/common genotype
Typical genotype, no Holoprosencephaly-3 risk variants in SSH
GG in rs34536443, typical (lower) odds of tuberculosis infection, common genotype
TT in rs334, no sickle cell anemia! Also no increased resistence to malaria
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
AA in rs660895, decreased risk of rheumatoid arthritis. Slightly decreased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
AC in rs7743761, 4.6x increased risk of Ankylosing Spondylitis. Risk allele is A
TT in rs6457617, 5.2x risk of rheumatoid arthritis and 1.5x risk of systemic sclerosis, very uncommon genotype
GG in rs11090865, common in clinvar, no risk variants for deafness
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
TT in rs4794067; Lower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave's Disease
CT in rs10156191 of AOC1, decreased DOA activity, may not tolerate NSAIDs so well. The risk allele is T. This is a fairly common genotype. ⚠
TT in rs144143780, no risk variants for Sanfilippo syndrome
GG in rs104894637 - not a carrier for Sanfilippo syndrome risk
CC in rs104894635, no risk variants for Sanfilippo syndrome
No von Gierke's disease. CC in Arg83Cys of glucose-6-phosphatase G6PC gene
GG in Cys1036Phe of BLM, not a carrier of variants for Bloom syndrome
AT, or heterozygous in rs12150220, slightly increased risk for several autoimmune diseases including Addison's disease
CC in rs1800546, normal
TT in rs74315405, no Gerstmann–Straussler–Scheinker syndrome
AA in rs3764147, 0 risk variants for leprosy
GG in rs11606250, most common , but higher risk for certain autoimmune diseases
AA, 0 risk variants in rs2302009
Celiac Disease Panel
average, no HLA-DRB1*0301 alleles, normal risk of celiac disease and lupus
no HLA-DQ8 haplotype, normal (lower) risk of Celiac disease
No risk variants in CCR3
1 risk variant in R262W
Allergies Panel
AG in rs2367563, slightly higher odds of allergic skin reaction to nickel - risk variant is A
TG in rs2155219, 1 allele for higher odds of allergies. Odds Ratio for every T allele = 1.18
GG in rs7192, lower risk of developing a peanut allergy
Androgen Receptor Gene (AR) Panel
CC in rs137852591, very typical ; no Androgen insensitivity
GG in rs9332969, normal , no Reifenstein syndrome
GG in rs9332971, normal , no Reifenstein syndrome
Crohn's Disease Panel
CC in NOD2's Arg702Trp. Typical (lower) risk for Crohn's disease
GG in rs2066845, normal (lower) risk for Crohn's disease. Risk allele is C
0 C inserts in exon 11 of the NOD2, lower risk for Crohn's disease
Canavan Syndrome Panel
AA in rs63751297, 0 risk variants
0 risk variants in Y231X
0 risk variants in A305E
0 risk variants in E285A
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
1 protective variant in HLA-C's rs9264942 (Good), atypical genotype. 60% reduction in HIV viral load
common (Good), no risk variants in rs2395029 (TT )
GG in rs2572886, Good , 0 risk variants (A), common
Complete resistance to HIV, two delta 32 alleles
HLA Gene Panel
The HLA genes are located on chromosome 6 in humans and encode proteins called human leukocyte antigens (HLAs). These proteins play a vital role in immune responses by presenting antigens to immune cells, specifically T cells. There are two main classes of HLA proteins: class I and class II.
The HLA system plays a critical role in several medical contexts, including organ transplantation, where matching HLA types between donor and recipient is crucial to minimize the risk of rejection. Additionally, HLA genes are associated with susceptibility to certain autoimmune diseases, infectious diseases, and drug hypersensitivity reactions, making them important targets for medical research and personalized medicine.
Here is a list of conditions affected by, and predicted by this Panel: Rheumatoid arthritis, systemic lupus erythematosus (SLE), type 1 diabetes mellitus, multiple sclerosis (MS), Sjögren's syndrome, inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis, celiac disease, ankylosing spondylitis, systemic sclerosis, psoriasis, Graves' disease, Hashimoto's thyroiditis, Addison's disease, vitiligo, myasthenia gravis, primary biliary cholangitis, autoimmune hepatitis Susceptibility or severity of certain viral infections (e.g., HIV, hepatitis B and C), some bacterial infections (e.g., leprosy, tuberculosis) Food allergies (e.g., peanut allergy, milk allergy), Allergic rhinitis (hay fever), Atopic dermatitis (eczema), Asthma Allograft rejection, Preeclampsia, and Certain neurological disorders (e.g., narcolepsy)
Highest odds of Autoimmune Disease 6.250 %
Intermediate (Slightly higher) Odds of Autoimmune Disease 42.500 %
Lower Odds of Autoimmune Disease 51.250 %.
MTRR Gene Panel
AG in rs1801394, slightly higher odds for meningomas and neural tube defects. 1 risk allele for disorders of Intracellular Cobalamin Metabolism
CC in rs10380, lower odds of pancratic cancer; 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AA in rs162036, no risk variants for spina bifida & Disorders of Intracellular Cobalamin Metabolism
CC in rs2287780, no risk variants for Disorders of Intracellular Cobalamin Metabolism
TT in rs2303080, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
GG in rs1802059, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
CC in CBS's rs234709, slightly increased homocysteine levels
Predisposed to intermediate levels of Plasma homocysteine, CT in rs2851391, T allele leads to lower levels
homocystinuria Panel
We found
No risk variants found in file!
and a total of 0 risk variants for homocystinuria in CBS gene out of 30 variants identified in your file in total.
Elevated homocysteine levels 33.333 %
Intermediate homocysteine levels 48.148 %
Lower homocysteine levels 18.519 %.
Muscular Dystrophy Myopathies
0 risk variants in rs121913574
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk variants in rs28937903
0 risk variants in rs28937904
0 risk variants in rs28928901
0 risk alleles in rs2296949
0 risk alleles in rs104894466
0 risk variants in rs28937900
Found : 0 risk variants for adrenoleukodystrophy out of 26 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 2
0 risk variants in OPN1MW out of 0
1 risk variants in OPN1SW out of 8
FTO Gene Panel
Higher Odds of Obesity 12.000 %.
Intermediate Odds of Obesity44.000 %.
Lower Odds of Obesity44.000 %.
No fat gene variants in rs1421085, lower odds of obesity
GG in rs1121980, lower BMI, decrease in the risk of obesity
TT , No 'fat gene' variants in FTO's rs9939609
Within PFKP Gene - also implicated in Obesity
GG in rs6602024, lower BMI
Others also implicated in Obesity
AA in rs4994, typical genotype - lower odds of obesity
CC in rs1799883, This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates
CT in rs6232, slightly higher risk of obesity and insulin sensitivity
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
AC in rs12465214 of ZNF804A, slightly decreased odds of Syncope (good allele is A). Odds ratio of ~0.98, this is the lowest pval (most statistically significant) snp for syncope risk
AA in rs1431318, around 7% increase in the risk of syncope
Used 4 snps in the following prediction
Syncope risk is 1.123 times the average
Bio Traits Panel
AA in MTR's rs1805087, decreased MTR activity and increased homocysteine levels (doesn't contribute to homocysteine panel score)
TT in rs174528, increased levels of omega 3 fatty acid, increased levels of docosahexaenoic acid
TT in rs174547, higher resting heart rate, higher omega-6 and omega-3 levels
ACE D/D genotype, increased ACE activity - healthier, reduced odds of hypertension and a range of other issues
CC in rs1544410, Decreased risk of low bone mineral density disorders
GG in rs1051730, Smokes normal (lower) number of cigarettes if a smoker, reduced odds of lung cancer
rs5443 (CC) lower risk of hypertension and obesity, lower response to viagra, less weight gain when treated with clozapine
CC in rs11777116, typical (lower) odds for migraine
TT in rs185819, ~30mm taller
CT in rs1042725, intermediate height genotype, carrier of 'tall allele', ~0.4cm taller than TT genotype carriers
CT in rs6060369, intermediate height genotype, carrier of 'tall allele', ~0.44cm taller than TT genotype carriers
AA in rs10946808, taller
CG in rs1800795, typical risk for T2D, insulin resistence, Alzheimer's, typical IL6 levels
AA in rs1380703, longer (typical) sleep duration
AG in rs66800491, higher odds of motion sickness (This is the variation with highest impact for motion sickness)
CC in rs2148710, lower predisposition to anger
Wet earwax. Normal (smellier) body odour. Normal colostrum. Typical for non-East Asians. CC in rs17822931
One copy of "hunter-gather" CLTCL1 gene variant + one "farmer" variant. Intermediate ability to process carbs and sugars. Farmer allele is C
AA in rs662799, normal (Lower odds of heart attack and obesity)
CC in rs27072, 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD
GG in rs4481887, least likely to be able to smell asparagus metabolites in urine
AG in rs6591536, more able to detect β-ionone (floral) fragrance
GG in rs11800854, higher (typical) odds of periodontitis
GG in rs234706, no alleles for reduced odds of cleft palate
Age-related Macular Degeneration
CC in rs1061147, Reduced 0.34x risk of Age-related Macular Degeneration
TT in rs1061170; lower risk for AMD, generally longer live than (C) allele carriers
GG in rs2230199, normal (reduced) risk for AMD
CC in rs380390, much higher odds of AMD
CC in rs3793917, lower (typical) odds for AMD
GG in rs800292, 2x increased odds of Age-related macular degeneration (MTAG)
Cataracts Panel
CC in rs8044853, ~1.3x higher odds of cataracts
GG in rs1929494, slightly reduced (~0.93x) risk for cataracts
CC in rs926937, higher(typical) risk of cataract
Vitamins and Levels
TG in rs2282679 of GC gene, likely lower levels of Vitamin D. ⚠
AC in rs7041, one allele for reduced vit D levels (A), intermediate odds for COPD if you smoke - average levels of vitamin D ⚠
TG in rs12785878, likely lower levels of Vitamin D. ⚠
GG in rs10741657, tend to have lower vitamin D levels ⚠
CT in rs7129781, average odds of Vitamin D insufficiency ⚠
CT in rs6544713, slightly higher LDL cholesterol ⚠
GG in rs6756629, associated with increased LDL levels, decreased HDL cholesterol levels, and increased triglyceride levels. ⚠
TT in rs560887, decreased blood sugar
CT in rs10047474, increased blood pressure. Risk allele is T. ⚠
GG in rs4961, lower blood pressure
AA in rs4895441, lower red blood cell count ⚠
CC in rs140522, lower red blood cell count ⚠
CC in rs1063739, protection of neurons against glutamate toxicity, increased (normal) rate of glutamate degradation
AA in rs602662, Higher vitamin B12 levels. 49.77 pg/ml increase per A allele relative to GG genotype
CC in rs34324219, higher (Typical) vitamin B12 levels
CC in rs4654748, 1.45 ng/ml decrease in B6 levels ⚠
Predisposed to lower levels of Vitamin A/Retinol, CC in rs780093 ⚠
GT in rs6862909, atypical genotype, lower - atypical Vitamin K levels, risk allele is T ⚠
CG in rs964184, higher levels of vitamin K
TT in ARSD's rs1637781, lower Ascorbic acid 3-sulfate levels ⚠
DVT Panel
TT in rs11121615, decreased risk of varicose veins. Highest pval and beta snp for this trait
CC in rs6025, lower (normal) risk of deep vein thrombosis
AT in rs7654093, typical odds of deep vein thrombosis (risk allele is T)
GG in rs1799963, lower risk of deep vein thrombosis
GG in rs7025486, lower odds of aneurysm and vascular disorders
Blood Group Panel
CC in rs9919007, likely blood type A or O. 0.74 accuracy
CC in rs635634, higher odds for all blood types besides A. 0.92 accuracy
TT in rs8176720, likely A or O blood type. 0.77 accuracy
GG in rs7030248, Likely no Blood type B or AB. Accuracy 0.74
TT in rs493014, no blood type B or AB. Accuracy 0.75
GG in rs8176746, likely not blood type AB. Accuracy 0.75
AA in rs8176740, slightly lower odds of B and O blood types
