AA in COMT's Val/Met variation, meaning Met/Met , or worrier , lower activity of the COMT enzyme. Since COMT enzyme's main function is the breakdown of dopamine, this leads to increased dopamine levels, advantages in attention tasks and motivation.
TT in rs4633, higher levels of the COMT protein and higher pain sensitivity - worrier
TT in COMT's rs4646312, slightly lower odds of schizophrenia
GG in COMT's rs6267, which is the typical for most humans and leads to slightly lower risk of Schizophrenia
AA in COMT's rs165599 variation, which leads to a decreased risk of Schizophrenia and Bipolar disorder.
CC in MAOB's rs1799836; Lower odds of ADHD, Parkinson's, One study found higher odds of Schizophrenia
GG in MAOB's rs6324, typical (lower) ADHD risk, most common genotype
TT in MAOA's rs6323, leading to lower activity of the MAOA enzyme and slower breakdown of dopamine, thus higher dopamine levels and certain advantages in attention tasks.
AA in MAOA's rs1800659, lower odds of post-surgical pain.
GG in MAOA's rs979605, decreased MAOA activity, worrier .
CC in MAOA's rs766117, higher odds of depression
Less D2 dopamine receptors 25.000 %.
Intermediate number of D2 dopamine receptors 45.588 %.
Higher number of D2 dopamine receptors 29.412 %.
AG, or 1 derived No Go learner variant in DRD2's Pro319Pro variation, which means an intermediate number of D2 receptor sites in the brain, and an intermediate likelihood of schizophrenia.
CG in rs6279 of DRD2, typical odds for Schizophrenia (risk allele is G)
AG in DRD2's rs6275 variation, meaning intermediate number of dopamine D2 receptors and average risk of Schizophrenia.
CC in DRD2's rs2514218, higher odds of Schizophrenia
GG genotype in rs4648317 of DRD2, which is the typical genotype for most humans, and leads to a slightly lower risk of Schizophrenia and nicotine dependence.
GG in Taq1 variation of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors, and to a slightly lower risk of ADHD and Alcoholism.
CT in DRD2's rs12363125, one allele for higher odds of cocaine abuse and migraine risk
AA in DRD2's rs6589377, higher (typical) odds of neuroticism, but lower odds for nicotine dependence.
CC in rs1076560 of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors and better memory performance.
TC, or heterozygous in rs5326 of DRD1, which is implicated in slightly higher odds of bipolar disorder andd schizophrenia.
AA in rs686 of Dopamine Receptor D1 gene, which leads to a higher likelyhood of Autism.
TT in rs4532 of DRD1, a typical associated with slightly higher odds of Autism and tobacco addiction.
GG in rs265981 of DRD1, which is the typical for most humans, and leads to a slightly higher risk of Schizophrenia and nicotine dependence.
CC in DRD1's rs4867798, elevated risk of schizophrenia, higher odds of impulsive-compulsive behavior in those affected by Parkinson's disease
GG in DRD1's rs265974, ~1.29x odds of substance use disorders.
TG in DRD1's rs265976, Patients with schizophrenia may have a poorer response when treated with clozapine as compared to patients with the GG or TT genotype. Other genetic and clinical factors may also influence response to clozapine. ⚠
TT in rs6280 of DRD3, a typical associated with a slightly lower risk of OCD and intellectual disability.
AA in DRD3's rs167771 variation, mostly a Eurasian genotype , increases the risks of autism and autistic personality traits such as rigid behavior.
AA in DRD3's rs963468, higher odds of schizophrenia, uncommon genotype (doesn't play a role in the polygenic risk score calculation).
AA in rs11246226 of DRD4, which is implicated in a higher likelyhood of Schizophrenia.
No risk variants for mental retardation in DRD4's rs752306 (CC)
TT in rs1800955 of DRD4, a typical associated with lower odds of intellectual disability and ADHD
GG in DRD4's rs936461, lower odds of schizophrenia but slightly higher odds of various eating disorders(OR=1.35).
CC in DRD5's rs6283. Higher odds of ADHD; mechanism of action is not exactly known
Lower levels of 5-HT (Serotonin) 48.276 %.
Intermediate levels of 5-HT (Serotonin) 44.828 %.
Higher levels of 5-HT (Serotonin) 6.897 %.
TT in rs2129785, a typical for most humans. The implications of this is that this individual does not have long form 5-HTTLPR and does not have a decrease in the risk of depression.
CT in rs6311 of HTR2A, slightly increased risk of suicidal behavior and depression. Normal risk of sexual dysfunction when taking SSRI Antidepressants.
AA in rs6313 of HTR2A, Higher odds for a variety of mental health conditions, highest odds of suicidal ideation
GG in HTR2A's rs2070040, G allele is associated with lower resistance to stress, irritability, and agressive behavior.
GG in HTR2A's rs4142900, G allele is associated with higher antisocial behavior and impulsivity
GG in rs1545843, NOT associated with higher risk for major depression (risk allele is A)
AA in rs17144465, typical (lower) depression risk.
AA in ESRRG's rs2377360, lower odds of depression
TT in rs364477, reduced odds of unipolar depression
CC in rs9834970 of TRANK1, slightly higher odds of Bipolar disorder and Schizophrenia
CC in DISC1 rs1411771, higher odds of bipolar and schizophrenia (does not play a role in polygenic risk scores)
GG in rs75459873, no risk variants for psychosis in MIR378F. Very typical genotype.
Homozygous major allele at ADCY2 gene. Associated with decreased bipolar risk.
AA in ADCY2's rs17826816, lower(typical) odds for bipolar disorder.
CC in rs267606861, common in clinvar, no tourette
GG in rs11074889, slightly lower odds of ADHD - risk allele is A
Results Mental Health - Autism Only
Higher Odds of Autism 35.135 %.
Intermediate Odds of Autism35.135 %.
Lower Odds of Autism29.730 %.
CC in rs4307059, Reduced Autism risk
TT in rs10513025, typical , normal (higher) risk of autism.
TT in rs7794745, slightly increased risk for autism. Risk allele is T.
CC in rs1804197, common genotype. Normal (lower) risk of autism.
AA in rs2217262, typical genotype. Average (higher) risk of autism.
GG in rs930707, typical (higher) Indoleacetate levels. Indoleacetate is a tryptophan derivative and lower levels of indoleacetate are linked with depressive symptoms.
TT in rs921451, More likely to smoke heavily if is a smoker.
CC in rs1451371, lower tendency to smoke heavily if is a smoker.
GG in rs2060762, More likely to smoke heavily if is a smoker.
Results For Lactose Persistence
GG in MCM6's rs4988235 variation, which means this individual does not carry the European lactose persistence mutation.
CC in MCM6's rs182549, This Individual does not have any derived variants for European lactose persistence.
AA in rs41380347, NOT carrier of the lactase persistence allele also known as "-13915*G", common in Arab populations
CC in rs2322659 of LCT, likely lactose persistent - C allele is not exclusive to Europeans
Higher Odds of Lactose Intolerance: 35.135 %.
Intermediate Odds of Lactose Intolerance: 45.946 %.
Lower Odds of Lactose Intolerance: 18.919 %.
Results for OXTR - The Empathy Gene
Lower Empathy 21.053 %.
Average Empathy 36.842 %.
Higher Empathy 42.105 %.
GG in OXTR's rs53576 variation, which means this individual has 2 variants for higher levels of empathy at this variation.
TT in rs1042778 of OXTR, Slightly lower oxytocin & empathy? Possibly higher 'callous-unemotional' trait frequency in children
CC in OXTR's rs13316193, a associated with increased OXTR expression and higher levels of empathy.
AG in OXTR's rs7632287 variation, which means this individual has 1 variant for higher OXTR expression and increased levels of empathy.
GG in OXTR's rs237897, two variants for higher levels of empathy in this OXTR variation. Most likely not East Asian.
Results for Diabetes
CC in rs6679677; normal(lower) risk for Rheumatoid Arthritis and Type 1 Diabetes
AA in HLA's rs9272346, Type 1 Diabetes very unlikely.
TT in rs7202877, slight decrease in risk of Type 1 Diabetes.
GG in rs12255372, decreased risk of Type 2 Diabetes.
AA in rs17696736, slighly lower odds of type 1 Diabetes
GG in rs35011184, lower odds of Type 2 diabetes and obesity.
GG in rs2476601 variation, which leads to lower risk of various autoimmune disorders and type 1 diabetes.
AG in rs17388568, 1 risk variant (A), 1.3x risk of type-1 diabetes.
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes.
CC in rs7754840, which means this individual has two variants for higher odds of type 2 diabetes.
CC in rs7903146, a associated with lower risk of type 2 diabetes.
GG in rs4402960, leading to slight decrease in the risk of Type 2 Diabetes.
Results for Hemochromatosis
GG in HFE's Cys282Tyr variation, which means this individual is not a carrier for the C282Y hemochromatosis mutation.
CC in HFE's His63Asp, which means this individual does not have any H63D variants and most likely doesn't have hemochromatosis.
AT, or heterozygous in HFE's S65C variation, which means that this individual carries one risk variant for hemochromatosis.
Results for Alzheimers
CC in rs7412, which means no APOE2 alleles in Arg176Cys variation of the APOE gene and lower, or in other terms, normal odds of alzheimers disease.
TT in rs3025786, which is a typical for most humans and leads to average (slightly increased) risk of Alzheimers.
GG in PLD3's rs145999145 variation, which means this individual has a lower risk of Alzheimers.
TT in rs669, which leads to slightly decreased risk of Alzheimers.
AG in TOMM40's rs2075650, higher odds of Alzheimer's disease.
CC in rs75932628, normal (Slightly lower) risk of Alzheimer's disease
CC in rs63750847, no variants for reduced risk of Alzheimer's disease. Normal (Higher) odds of Alzheimers
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS. Lower (typical) odds for narcolepsy as well.
No risk variants in HLA-DQA1; lower risk of MS
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
0 risk variants for MS in HLA-DRB1. Typical
AG in rs4959039, 1 (common) risk variant for MS.
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
TT in rs602633, 2 risk variants for Coronary Heart Disease (Odds ratio = 1.11 for every T allele). Sort of uncommon.
GG in rs700651, ~20% higher risk of brain aneurysm, risk allele is G
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
TT in rs1333040, higher odds of brain aneurysm and heart attack.
AA in rs9298506, normal (higher) risk of aneurysm.
TC in rs6475606, decreased risk for Coronary artery disease, risk allele is T.
TC in rs10757272, 1.30x increased risk for Coronary artery disease, risk allele is T.
CC in rs9315204, lower risk of aneurysm, common genotype.
AG in rs10757274, 1.2x increased risk for heart disease. Risk allele is G.
AG in rs2383206, 1.4x increased risk for heart disease. Risl allele is G.
AG in rs10757278, 1.3x risk for Heart Attack. Normal risk for Abdominal Aortic Aneurysm and Brain Aneurysm.
CC in rs1800787, not a carrier of risk variants for carotid arthery disease (T).
GG in rs5082, Reduced risk of heart disease.
AG in rs17576, average odds of heart attack and lung cancer.
TT in rs3918242, much higher odds of heart attack.
Asthma + Epilepsy Panel
TT in rs7216389, 1.5x increased risk for Childhood Asthma.
AG in rs1695, mixed evidence showing either increased or decreased risk of asthma
TT in rs10030601, below average odds of epilepsy
CC in rs10496964, typical (higher) odds of epilepsy
CC in rs7587026; decreased (typical) odds of epilepsy
AA in rs12059546, lower (typical) odds of epilepsy
GG in rs72823592, 1.3x odds of epilepsy
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness.
AA in rs7744813, which leads to a decrease in the risk of myopia.
TT in rs524952, which means an increased risk of myopia.
AA in rs4803455, two alleles that protect from Myopia.
CG in RBFOX1's rs17648524, one allele that protects against myopia.
CC in rs3138142, higher odds of myopia.
Facial Morphology Panel
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
AG in rs6542787, 1 European EDAR alleles. Likely partially European
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
TT in rs892540, shorter midface length
AA in PAX3s rs7559271, higher odds of protruding nasal bridge
CC in rs4648379, larger nose size.
Likely higher nasolabial angle (nose pointing up) based on DCHS2 genotype
CC in rs938036, likely has mandibular third molar, lower odds of tooth agenesis (missing teeth)
TT in rs12651896, slightly thinner eyebrows
GG in rs7702108, slightly thinner eyebrows
Miscellaneous
(Don't voice this in video!!) CC in rs9332964, no micropenis.
(Don't voice this in video!!!) GG in SRD5A2's rs104893667 variation, which means this individual does not have micropenis.
CC in rs10784502, increased cranial size and 2% higher IQ.
CC in rs28379706, higher IQ.
AA in rs324640, 8 points lower IQ than individuals with 'GG' .
CC in rs1815739, Better performing muscles. Likely sprinter.
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
TT in rs10427255, likely does not have photic sneeze reflex.
GG in SCN9A rs6746030 variation, no variants for increased pain sensitivity.
TT, no MYBPC2 mental retardation variants, likely healthy.
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer.
AA in rs1080066, average brain volume (slightly smaller). common genotype.
CC in rs6265, higher odds of obesity and major depressive disorder
Drug Responce
Risk of Heart Failure Due to Beta Blocker Medications is 0.626 times the average.
When treated with metoprolol
Relative to AA in rs1801252 & GG in rs1801253 Genotypes :
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : AA in rs1801252 &
TT in EGFR's rs2293347, among NSCLC patients, worse Gefitinib response; uncommon
AA in CYP2C9's rs1057910, normal; no effect on warfarin metabolism
CC in CYP2C9's rs1799853, Good, no risk of altered warfarin metabolism or NSAID metabolism
GG in rs3745274, no increased risk when taking efavirenz for HIV treatment
AA in rs1801272, no reduced CYP2A6 metabolism, no impaired nicotine metabolism, typical genotype
CC in CYP1A2's rs28399424, Good, normal CYP1A2 activity
GG in rs4986893, no CYP2C19*3 allele (Good)
GG in rs4244285, normal in CYP2C19 (Good) no issues metabolizing antidepressants, mephenytoin, or Plavix
GG in CYP2D6's rs1065852, NOT carrier for CYP2D6 decreased or non-functioning variants (good)
CC in rs4363657, 17x increased myopathy risk for statin users ⚠
AG in rs637644, average odds of hair loss from chemotherapy- risk allele is G. ⚠
AA in rs594206, highest odds of hair loss from chemotherapy. ⚠
TG in DRD1's rs265976, Patients with schizophrenia may have a poorer response when treated with clozapine as compared to patients with the GG or TT genotype. Other genetic and clinical factors may also influence response to clozapine. ⚠
GG in rs2273697, Adverse reaction less likely to carbamazepine in epileptic patients
TT in rs2298383, no variants for increased anxiety in response to caffeine.
AC in rs762551, Carrier of one CYP1A2*1F allele; Normal (faster) metabolism of caffeine ⚠
CC in rs1467558, lower (normal) risk of liver toxicity from acetominophen/tylenol/APAP
CC in rs10156191 of AOC1, normal (increased) DOA activity, normal genotype. Tolerates NSAIDs.
TT in rs12476047. Lower than average odds of parkinson's symptoms when treated with antipsychotics
TT in rs5092, more likely to gain weight if taking olanzapine. ⚠
TT in rs4765623, less likely to gain weight if taking olanzapine.
GG in rs518147, significantly higher odds of weight gain if taking olanzapine. ⚠
CC in AKT1's rs2494732, greater odds of cannabis-associated psychosis. ⚠
GG in rs2241802, higher odds of methamphatamine induced psychosis. ⚠
CC in rs135745, higher susceptibility to methamphetamine induced psychosis. ⚠
AA in rs12591257, no protection from Methamphetamine induced psychosis ⚠
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation.
AA in TYR's rs28940881 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
AA in TYR's rs28940878 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism.
CC in TYR's rs104894313, Not Carrier of an oculocutaneous Albinism Type 1B mutation.
CC in TYRP1's rs104894130, which means this individual lacks variants for Oculocutaneous albinism type 3, and is not albino.
CC in rs987525, which leads to decreased risk of cleft lip and palate.
CC in TYRP1's rs387907171, not a Carrier of melanesian blond hair variants.
Familiar Mediterranean Fever Panel
0 risk variants in rs104895094.
0 risk variants in rs3743930.
0 risk variants in rs11466023
0 risk variants in rs61752717
0 risk variants in rs28940579.
0 risk variants in rs28940578.
0 risk variants in rs61732874.
0 risk variants in rs104895083.
0 risk variants in rs104895085
0 risk variants in rs104895081
0 risk variants in rs104895157
0 risk variants in rs11466026
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
GG in MTHFR's rs1801133, normal homocysteine levels, good . Slightly lower than average odds for a variety of illnesses from autism to coronary heart disease.
TT in MTHFR's rs1801131, most common genotype , lower odds of various health issues.
AA in rs17367504, common , average (higher) blood pressure.
CC in rs2274976, Good, lower odds of neural tube defects
GG in rs2066470, typical genotype.
Cancers Panel
Highest Odds of Epithelial Cancers: 21.951 %.
Intermediate (slightly higher) Odds of Epithelial Cancers: 46.341 %.
Lower (typical) Odds of Epithelial Cancers: 31.707 %.
Glioma
TT in 8q24 rs4295627, lower odds of glioma development
AG in EGFR's rs11979158, slight decrease in the odds of glioma, protective allele is G
CT in EGFR's rs2252586, slightly higher odds of glioma, risk allele is T
AA in rs498872, increase in the odds of glioma.
GG in rs4977756, 1.93x higher risk for glioma development
AG in rs6010620, 1.2x higher risk for glioma development, 1.17x higher risk for atopic dermatitis in Han Chinese
Prostate
AA in rs4430796, 1.22x increased risk for prostate cancer.
AA in rs1859962, decreased risk for prostate cancer.
CC in HOXB13's rs138213197, normal (lower) risk of prostate cancer in men
No rare variant for prostate cancer
CC in 8q24 rs16901979, no risk alleles for prostate cancer (Good)
GG in 8q24 rs6983267, 1.6x increased risk for prostate cancer; also other cancers
CC in 8q24 rs1447295, no risk alleles for prostate cancer (Good)
Breast - BRCA
0 risk variants in Q356R of BRCA1
2 risk variants in BRCA1's D693N.
0 risk variants in S1140G of BRCA1
2 risk variants in K1183R of BRCA1
1 risk variant in S1613G of BRCA1
0 risk variants in N289H of BRCA2.
GG in rs1042522 of TP53. common genotype. Slightly shorter lifespan. Higher odds of various cancers.
TT in rs1801155, average (lower) risk of colon cancer
0 risk variants in S707P
Testicular - KITLG
AG in rs995030, 2 times Reduced risk of testicular cancer.
TT in rs3782179; common, but increased risk of testicular cancer
AG in rs4474514, 3x increased testicular cancer risk for men
Other Cancers
AA in AURKA's rs2273535, slightly lower (normal) odds for various cancers
AA in Estrogen Receptor 1 Gene's -351A>G variation. Women have lower risk of Endometriosis but normal risk for Endometrial Cancer, and more cognitive impairment with age.
AG in EGFR rs763317, increased lung cancer risk for never-smoking females
TT in rs710521, 1.4x increased risk of developing bladder cancer.
CC in rs798766, Lower (normal) risk of developing urinary bladder cancer.
GG in rs1800629, good, lower odds of lymphoma among a variety of other illnesses.
TNF Risk Variants for Lymphoma: 0 Out of 6 variants found in file in total
No risk variants found in file
Presence of Any risk variants are a concern
Thyroid Cancer
GG in rs1867277, slightly lower odds of thyroid cancer.
GG in rs965513, normal(lower thyroid cancer risk).
TT in rs944289, 1.69x increased thyroid cancer risk
CC in rs116909374, typical(lower) odds of thyroid cancer
CC in rs966423, Possible elevated thyroid cancer risk
Leukemia Panel
no NQO1*3 alleles, average odds of leukemia.
GG in rs1800566, 0 NQO1*2 alleles (0 risk variants for leukemia)
TT in rs4132601, common -> lower risk of leukemia.
TT in rs7089424, common/normal and lower risk of Leukemia.
GG in rs662463, common , lower odds of leukemia.
Rare diseases/traits Panel
GG in rs75801644, 0 risk variants for endometriosis.
No rare variant for prostate cancer
AA in F9 rs137852229, not a Carrier of a Hemophilia B mutation - 0 risk variants
GG in rs9540294, 5x+ odds of Recalcitrant atopic dermatitis, very uncommon genotype
GG in rs79919349, 0 risk variants for panic disorder (very common genotype).
Strong predisposition to hemoglobin E disease, GG in rs2071348
CC in rs119478057, no predidposition to Hypercarotenemia and vitamin a deficiency
GG in rs387906725, no Lesch-nyhan syndrome.
GG in rs28942100, not a Carrier of a alkaptonuria mutation - 0 risk variants
CC in rs199473058, no Brugada Syndrome
GG in rs121434528, 0 risk alleles for Thoracic aortic aneurysm and dissection
GG in rs74315329, not a carrier for Glaucoma (primary open-angle).
GG in rs893818, lower odds of exfoliation glaucoma.
GG in rs3825942, common but 10x higher glaucoma risk in most (but not all) populations.
CC in rs28936694, no Primary open-angle glaucoma
AG in rs16863657, carrier of risk allele for neural tube defects and spina bifida.
GG in rs80338794, not a Finnish major Salla disease mutation carrier - 0 risk variants.
0 variants for Ehlers-Danlos syndrome; CC in rs28937869
Found 0 risk variants for Holoprosencephaly in GLI2. Very typical/common genotype
Typical genotype, no Holoprosencephaly-3 risk variants in SSH
GG in rs34536443, typical (lower) odds of tuberculosis infection, common genotype
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
GG in rs10033464, 0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke.
GG in rs660895, 4-6x risk of rheumatoid arthritis. Significantly increased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
CC in rs7743761, Normal (lower) risk of Ankylosing Spondylitis.
TT in rs6457617, 5.2x risk of rheumatoid arthritis and 1.5x risk of systemic sclerosis, very uncommon genotype.
GG in rs11090865, common in clinvar, no risk variants for deafness.
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
TT in rs4794067; Lower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave's Disease.
CC in rs10156191 of AOC1, normal (increased) DOA activity, normal genotype. Tolerates NSAIDs.
GG in rs104894637 - not a carrier for Sanfilippo syndrome risk
CC in rs104894635, no risk variants for Sanfilippo syndrome
No von Gierke's disease. CC in Arg83Cys of glucose-6-phosphatase G6PC gene.
GG in Cys1036Phe of BLM, not a carrier of variants for Bloom syndrome.
TT in rs12150220, slightly decreased risk for several autoimmune diseases including Addison's disease.
CC in rs1800546, normal.
TT in rs74315405, no Gerstmann–Straussler–Scheinker syndrome.
AA in rs3764147, 0 risk variants for leprosy.
GG in rs11606250, most common , but higher risk for certain autoimmune diseases.
AA, 0 risk variants in rs2302009.
Celiac Disease Panel
average, no HLA-DRB1*0301 alleles, normal risk of celiac disease and lupus.
no HLA-DQ8 haplotype, normal (lower) risk of Celiac disease.
No risk variants in CCR3
No risk variants in IL18R1
AA in rs13119723, lower (normal) risk for celiac disease. 0 risk variants
No risk variants in R262W
Allergies Panel
GG in rs62623409, typical odds of allergic sensitivity
AA in rs2367563, nickel likely causes an allergic skin reaction.
TG in rs2155219, 1 allele for higher odds of allergies. Odds Ratio for every T allele = 1.18
CG in rs17513503, higher odds of allergies; rare
TT in rs7192, 3x higher risk for developing a peanut allergy.
TT in rs9275596, lower risk of peanut allergy. Risk allele is C.
Androgen Receptor Gene (AR) Panel
GG in rs6152, typical (higher) odds of baldness.
CC in rs137852591, very typical ; no Androgen insensitivity.
GG in rs9332969, normal , no Reifenstein syndrome.
Crohn's Disease Panel
GG in rs2066845, normal (lower) risk for Crohn's disease. Risk allele is C.
Canavan Syndrome Panel
AA in rs63751297, 0 risk variants.
0 risk variants in Y231X.
0 risk variants in A305E.
0 risk variants in E285A.
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
0 protective variants in C927T (Bad), most typical genotype.
2 protective variants in HLA-C's rs9264942 (Good), 90% reduction in HIV viral load.
common (Good), no risk variants in rs2395029 (TT )
GG in rs2572886, Good , 0 risk variants (A), common.
HLA Gene Panel
The HLA genes are located on chromosome 6 in humans and encode proteins called human leukocyte antigens (HLAs). These proteins play a vital role in immune responses by presenting antigens to immune cells, specifically T cells. There are two main classes of HLA proteins: class I and class II.
The HLA system plays a critical role in several medical contexts, including organ transplantation, where matching HLA types between donor and recipient is crucial to minimize the risk of rejection. Additionally, HLA genes are associated with susceptibility to certain autoimmune diseases, infectious diseases, and drug hypersensitivity reactions, making them important targets for medical research and personalized medicine.
Here is a list of conditions affected by, and predicted by this Panel: Rheumatoid arthritis, systemic lupus erythematosus (SLE), type 1 diabetes mellitus, multiple sclerosis (MS), Sjögren's syndrome, inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis, celiac disease, ankylosing spondylitis, systemic sclerosis, psoriasis, Graves' disease, Hashimoto's thyroiditis, Addison's disease, vitiligo, myasthenia gravis, primary biliary cholangitis, autoimmune hepatitis Susceptibility or severity of certain viral infections (e.g., HIV, hepatitis B and C), some bacterial infections (e.g., leprosy, tuberculosis) Food allergies (e.g., peanut allergy, milk allergy), Allergic rhinitis (hay fever), Atopic dermatitis (eczema), Asthma Allograft rejection, Preeclampsia, and Certain neurological disorders (e.g., narcolepsy)
Highest odds of Autoimmune Disease 8.738 %
Intermediate (Slightly higher) Odds of Autoimmune Disease 38.835 %
Lower Odds of Autoimmune Disease 52.427 %.
MTRR Gene Panel
GG in rs1801394, 1.4x higher risk for meningiomas and neural tube defects. 2 risk alleles for disorders of Intracellular Cobalamin Metabolism
CC in rs10380, lower odds of pancratic cancer; 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AA in rs162036, no risk variants for spina bifida & Disorders of Intracellular Cobalamin Metabolism.
CC in rs2287780, no risk variants for Disorders of Intracellular Cobalamin Metabolism
TT in rs2303080, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AG in rs1802059, 1 risk allele for disorders of Intracellular Cobalamin Metabolism
CBS Panel
CC in CBS's rs234714, lowest Plasma homocysteine levels (highest impact snp)
TT in CBS's rs234709, decreased homocysteine levels (small impact)
Predisposed to higher levels of Plasma homocysteine, CC in rs6586282
Predisposed to lower levels -0.02 µmol/L decrease of Plasma homocysteine, TT in rs2851391
homocystinuria Panel
We found
No risk variants found in file!
and a total of 0 risk variants for homocystinuria in CBS gene out of 26 variants identified in your file in total.
Elevated homocysteine levels 6.897 %
Intermediate homocysteine levels 41.379 %
Lower homocysteine levels 51.724 %.
Muscular Dystrophy Myopathies
0 risk variants in rs121913574
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk variants in rs28937903
0 risk variants in rs28937904
0 risk variants in rs28928901
0 risk alleles in rs2296949
0 risk alleles in rs104894466
0 risk variants in rs28937900
0 risk variants in rs193922094
Found : 0 risk variants for adrenoleukodystrophy out of 30 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 4
0 risk variants in OPN1MW out of 0
1 risk variants in OPN1SW out of 8
FTO Gene Panel
Higher Odds of Obesity 21.053 %.
Intermediate Odds of Obesity50.000 %.
Lower Odds of Obesity28.947 %.
No risk variants for obesity in rs9930506, lower risk of obesity
Heterozygous in rs1421085, 1.3x higher risk of obesity
AG in rs9937053, slightly higher BMI
Homozygous for 'fat gene' variants in rs11642015, much higher risk of obesity. Likely European.
AG in rs1121980, slightly higher BMI. Slight increase (1.67x) in risk for obesity
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
AG in rs9928094, slightly higher odds of extreme obesity
Within PFKP Gene - also implicated in Obesity
GG in rs6602024, lower BMI
Others also implicated in Obesity
AA in rs4994, typical genotype - lower odds of obesity.
CC in rs1799883, This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.
TT in rs6232, lower risk of obesity and insulin sensitivity
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
AA in rs12465214 of ZNF804A, decreased odds of Syncope. Odds ratio of ~0.9, this is the lowest pval (most statistically significant) snp for syncope risk
AA in rs1431318, around 7% increase in the risk of syncope.
Used 6 snps in the following prediction
Syncope risk is 1.003 times the average
Bio Traits Panel
AA in MTR's rs1805087, decreased MTR activity and increased homocysteine levels (doesn't contribute to homocysteine panel score)
CC in rs174528, higher levels of choline, lower Omega-3 fatty acid levels, lower Docosahexaenoic acid levels
CC in rs174547, lower resting heart rate, lower omega-6 and omega-3 levels
ACE D/D genotype, increased ACE activity - healthier, reduced odds of hypertension and a range of other issues.
CC in rs1544410, Decreased risk of low bone mineral density disorders
GG in rs1051730, Smokes normal (lower) number of cigarettes if a smoker, reduced odds of lung cancer.
rs5443 (TT) are clearly at higher risk for hypertension, 2-3 fold more likely to be obese, rs5443(T;T) genotypes respond to Viagra better. rs5443(T;T) patients receiving clozapine over a long term for the treatment of schizophrenia gain significantly more weight (16%) compared to patients carrying at least one rs5443(C) allele in a study of Chinese patients. rs5443(T) carriers taking triptans for the treatment of migraines or cluster headaches were ~3 fold more likely to respond positively compared with rs5443(C;C) homozygotes (OR 2.96, CI:1.34 - 6.56, p=0.0074) in a study of ~200 Caucasian patients.
AA in CDH4's rs16985493, rare genotype associated with ~1.6x increased odds of migraine.
CT in rs11777116, uncommon genotype, significant increase in the odds of migraine - risk allele is T
TT in rs185819, ~30mm shorter
CT in rs1042725, intermediate height genotype, carrier of 'tall allele', ~0.4cm taller than TT genotype carriers
CC in rs6060369, ~0.88cm taller height relative to TT genotype
GG in rs10946808, carrier of two alleles for shorter stature. 0.72cm shorter than AA individuals.
CG in rs1800795, typical risk for T2D, insulin resistence, alzheimers, typical IL6 levels
AA in rs1380703, longer (typical) sleep duration
CC in rs2148710, lower predisposition to anger
Wet earwax. Normal (smellier) body odour. Normal colostrum. Typical for non-East Asians. CC in rs17822931
Two copies of "hunter-gatherer" CLTCL1 gene variant. Reduced ability to process carbs and sugars.
CC in rs307377, common in complete genomics - no extraordinary tasting ability
AA in rs662799, normal (Lower odds of heart attack and obesity)
CC in rs27072, 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD
AA in rs4481887, most likely to smell asparagus metabolites in urine
AA in rs6591536, less able to detect β-ionone (floral) fragrance
GG in rs11800854, higher (typical) odds of periodontitis
AA in rs234706, 0.50 reduced risk of cleft lip / palate, 0.51 reduced risk of non-Hodgkin lymphoma. Increased responsiveness to homocysteine-lowering effects of folic acid.
Age Related Macular Degeneration
GG in rs547154, no increased protection from Age-related maculopathy, most typical genotype.
CC in rs1061147, Reduced 0.34x risk of Age Related Macular Degeneration.
AG in rs11200638, ~2x increased risk of age related macular degeneration
GG in rs2230199, normal (reduced) risk for AMD
CC in rs380390, much higher odds of AMD
CG in rs3793917, ~1.8x the average odds for AMD
GG in rs800292, 2x increased odds of Age-related macular degeneration (MTAG)
Cataracts Panel
GG in rs62621812, typical genotype, lower (typical) risk for cataracts.
AA in rs4814857,typical genotype, lower (0.96x) risk for cataracts
CC in rs8044853, ~1.3x higher odds of cataracts
AA in rs1929494, 1.3x risk for cataracts
CC in rs926937, higher(typical) risk of cataract
Vitamins and Levels
GG in rs2282679 of GC gene, typically lower levels of Vitamin D. ⚠
AA in rs7041, ex-smokers at 2x higher risk for chronic obstructive pulmonary disease ; supplement with Vitamin D - [1985.17-2233.51] nmol/L decrease of vit D levels ⚠
TT in rs12785878, lower levels of Vitamin D. ⚠
GG in rs10741657, tend to have lower vitamin D levels ⚠
TT in rs7129781, decreased odds of Vitamin D insufficiency
CT in rs6544713, slightly higher LDL cholesterol ⚠
GG in rs6756629, associated with increased LDL levels, decreased HDL cholesterol levels, and increased triglyceride levels. ⚠
CC in rs560887, slightly higher blood sugar ⚠
TT in rs10047474, increased blood pressure ⚠
GG in rs4961 (imputed through rs4963), lower blood pressure
AG in rs4895441, intermediate red blood cell count ⚠
TT in rs140522, higher red blood cell count
CC in rs1063739, protection of neurons against glutamate toxicity, increased (normal) rate of glutamate degradation
GG in rs602662, Lower vitamin B12 levels. 49.77 pg/ml decrease in B12 levels per G allele relative to AA genotype ⚠
CC in rs4654748, 1.45 ng/ml decrease in B6 levels ⚠
CC in rs33972313, typical (higher) levels of Vitamin C
Predisposed to lower levels of Vitamin A/Retinol, CC in rs780093 ⚠
GG in rs11057830, lower(typical) levels of Vitamin E.⚠
GG in rs6862909, typical genotype, higher - typical Vitamin K levels
CG in rs964184, higher levels of vitamin K.
DVT Panel
TT in rs11121615, decreased risk of varicose veins. Highest pval and beta snp for this trait
CC in rs6025, lower (normal) risk of deep vein thrombosis
AA in rs7654093, slightly lower odds of deep vein thrombosis
GG in rs1799963, lower risk of deep vein thrombosis
GG in rs113092656, lower risk of deep vein thrombosis
GG in rs7025486, lower odds of aneurysm and vascular disorders
Blood Group Panel
CC in rs9919007, likely blood type A or O. 0.74 accuracy
CC in rs635634, higher odds for all blood types besides A. 0.92 accuracy
CT in rs8176720 possibly blood type A or O. 0.77 accuracy
GG in rs7030248, Likely no Blood type B or AB. Accuracy 0.74
TG in rs493014, possibly blood type B or AB. Accuracy 0.75.
GG in rs687289, Likely not Blood type AB. Accuracy 0.91
GG in rs8176746, likely not blood type AB. Accuracy 0.75.
TT in rs505922, Likely blood type O. 0.8 accuracy
TT in rs529565, Likely blood type O. 0.98 accuracy
AT in rs8176740, slightly higher odds of B and O blood types
GG in rs1053878, 0 alleles for cis-AB blood type, cis-AB blood type less likely.
