GG in COMT's Val/Met variation, meaning Val/Val , or warrior , higher activity of the COMT enzyme and quicker breakdown of dopamine. Individuals with this have advantages in stress resilience but disadvantages in attention tasks.
CC in rs4633, higher expression levels of the COMT protein and protection from endometrial cancer, lower pain sensitivity - warrior
CC in COMT's rs4646312, much higher odds of schizophrenia (Odds ratio 1.25 per risk allele, pval 8 x 10-6). Most likely European
GG in COMT's rs6267, which is the typical for most humans and leads to slightly lower risk of Schizophrenia
CC in MAOB's rs1799836; Lower odds of ADHD, Parkinson's, One study found higher odds of Schizophrenia
Less D2 dopamine receptors 42.000 %.
Intermediate number of D2 dopamine receptors 32.000 %.
Higher number of D2 dopamine receptors 26.000 %.
GG, which means no derived No-Go Learner variants in DRD2's Pro319Pro variation, which means a higher number of D2 receptor sites in the brain, and a higher likelihood of schizophrenia
CC in rs6279, lower odds of Schizophrenia
GG genotype in rs4648317 of DRD2, which is the typical genotype for most humans, and leads to a slightly lower risk of Schizophrenia and nicotine dependence.
AA in Taq1 variation of DRD2, which is implicated in a greatly decreased number of Dopamine D2 receptor sites in the brain and an increased likelihood of Alcoholism, Parkinson's, ADHD, and various other illnesses. This is not a typical human .
CC in DRD2's rs12363125, lower odds of cocaine dependence and migraine, higher D2 receptor availability
AA in rs1076560 of DRD2, which is implicated in a decreased number of Dopamine D2 receptor sites in the brain and an increased likelihood of Alcoholism as well as decreased memory function. This is not a typical human .
CC in rs5326 of DRD1, which is the typical for most humans and leads to a slightly lower risk of various mental health conditions.
GG in rs686 of Dopamine Receptor D1 gene, which is the typical and leads to lower likelyhood of autism.
AA in rs265981 of DRD1, which is implicated in decreased risk of various mental health issues. This is most typical for Europeans.
TT in DRD1's rs4867798, part of a haplotype for reduced risk of schizophrenia according to 2014 study
AA in DRD1's rs265974, ~0.77x lower odds of substance use disorders.
TT in rs6280 of DRD3, a typical associated with a slightly lower risk of OCD and intellectual disability.
AA in DRD3's rs963468, higher odds of schizophrenia, uncommon genotype (doesn't play a role in the polygenic risk score calculation).
AA in rs11246226 of DRD4, which is implicated in a higher likelyhood of Schizophrenia.
No risk variants for mental retardation in DRD4's rs752306 (CC)
CC in rs1800955 of DRD4, a associated with an increased likelyhood of multiple mental health conditions, including novelty seeking, addiction and intellectual disability.
TT in DRD5's rs6283. Lower odds of ADHD; mechanism of action is not exactly known
Lower levels of 5-HT (Serotonin) 45.000 %.
Intermediate levels of 5-HT (Serotonin) 40.000 %.
Higher levels of 5-HT (Serotonin) 15.000 %.
TT in rs2129785, a typical for most humans. The implications of this is that this individual does not have long form 5-HTTLPR and does not have a decrease in the risk of depression.
CC in rs6311 of HTR2A, robustly increased risk of suicidal behavior and depression. 3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants
AA in HTR2A's rs2070040, G allele is associated with lower resistance to stress, irritability, and agressive behavior.
GG in rs1545843, NOT associated with higher risk for major depression (risk allele is A)
AA in ESRRG's rs2377360, lower odds of depression
TT in rs364477, reduced odds of unipolar depression
TT in DISC1 rs1411771, somewhat lower odds of bipolar and schizophrenia (does not play a role in polygenic risk scores)
GG in rs75459873, no risk variants for psychosis in MIR378F. Very typical genotype.
Homozygous major allele at ADCY2 gene. Associated with decreased bipolar risk.
AA in ADCY2's rs17826816, lower(typical) odds for bipolar disorder.
CC in rs267606861, common in clinvar, no tourette
Results Mental Health - Autism Only
Higher Odds of Autism 25.000 %.
Intermediate Odds of Autism35.714 %.
Lower Odds of Autism39.286 %.
CC in rs4307059, Reduced Autism risk
TT in rs10513025, typical , normal (higher) risk of autism.
AA in rs7794745, slightly decreased risk of autism.
CC in rs1858830, 2x risk of autism reported by some (but not other) publications.
CC in rs1804197, common genotype. Normal (lower) risk of autism.
GG in rs930707, typical (higher) Indoleacetate levels. Indoleacetate is a tryptophan derivative and lower levels of indoleacetate are linked with depressive symptoms.
TT in rs921451, More likely to smoke heavily if is a smoker.
TT in rs1451371, More likely to smoke heavily if is a smoker.
Results For Lactose Persistence
GG in MCM6's rs4988235 variation, which means this individual does not carry the European lactose persistence mutation.
AA in rs41380347, NOT carrier of the lactase persistence allele also known as "-13915*G", common in Arab populations
TT in rs2322659 of LCT, likely lactose intolerant
Higher Odds of Lactose Intolerance: 46.667 %.
Intermediate Odds of Lactose Intolerance: 50.000 %.
Lower Odds of Lactose Intolerance: 3.333 %.
Results for OXTR - The Empathy Gene
Lower Empathy 30.769 %.
Average Empathy 38.462 %.
Higher Empathy 30.769 %.
AG in OXTR's rs53576 variation, which means this individual has 1 sociopath variant for reduced OXTR expression and lack of empathy together with 1 variant for higher levels of empathy.
GG in rs1042778 of OXTR, higher oxytocin and empathy
TT in OXTR's rs13316193, a associated with decreased OXTR expression and lower levels of empathy, as well as higher risk of autism spectrum disorder.
Results for Diabetes
GG in rs12255372, decreased risk of Type 2 Diabetes.
AA in rs17696736, slighly lower odds of type 1 Diabetes
GG in rs35011184, lower odds of Type 2 diabetes and obesity.
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes.
CC in rs7903146, a associated with lower risk of type 2 diabetes.
TT in rs4402960,leading to a significant increase in the risk of Type 2 Diabetes.
Results for Hemochromatosis
GG in HFE's Cys282Tyr variation, which means this individual is not a carrier for the C282Y hemochromatosis mutation.
CC in HFE's His63Asp, which means this individual does not have any H63D variants and most likely doesn't have hemochromatosis.
AA in HFE's S65C variation, which means that this individual does not carry any risk variants for hemochromatosis.
Results for Alzheimers
CC in rs7412, which means no APOE2 alleles in Arg176Cys variation of the APOE gene and lower, or in other terms, normal odds of alzheimers disease.
TT in rs429358, no risk alleles for Alzheimers in this APOE variation.
TT in rs3025786, which is a typical for most humans and leads to average (slightly increased) risk of Alzheimers.
GG in PLD3's rs145999145 variation, which means this individual has a lower risk of Alzheimers.
TT in rs669, which leads to slightly decreased risk of Alzheimers.
AA in TOMM40's rs2075650, slightly decreased odds of Alzheimer's disease.
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS. Lower (typical) odds for narcolepsy as well.
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
AA in rs4959039, 2 (common) risk variants for MS.
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
AA in rs700651, normal (lower) risk of aneurysm
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
CC in rs1333040, lower odds of brain aneurysm and heart attack, risk allele is T.
AA in rs9298506, normal (higher) risk of aneurysm.
CC in rs6475606, much lower risk of Coronary artery disease.
CC in rs10757272, Normal (lower) risk for Coronary artery disease.
CC in rs9315204, lower risk of aneurysm, common genotype.
AA in rs10757274, normal(lower) risk of heart disease.
GG in rs2383206, 1.7x increased risk for heart disease.
AA in rs10757278, 0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm..
AG in rs17576, average odds of heart attack and lung cancer.
Asthma + Epilepsy Panel
AA in rs1695, normal asthma risk in certain populations
TT in rs10030601, below average odds of epilepsy
TT in rs10496964, very below average odds of epilepsy (x0.6)
AA in rs12059546, lower (typical) odds of epilepsy
GG in rs72823592, 1.3x odds of epilepsy
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness.
CC in rs7744813, which leads to an increase in the risk of myopia.
CC in rs4803455, two alleles for increased Myopia risk.
GG in RBFOX1's rs17648524, two alleles that protect against myopia.
CC in rs3138142, higher odds of myopia.
Facial Morphology Panel
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
CC in rs892540, longer (typical) midface length
AG in PAX3s rs7559271, intermediate odds of protruding nasal bridge, A allele increases the odds of protruding nasal bridge
TT in rs4648379, smaller nose size.
CC in rs938036, likely has mandibular third molar, lower odds of tooth agenesis (missing teeth)
CC in rs12651896, thicker eyebrows
Miscellaneous
(Don't voice this in video!!) CC in rs9332964, no micropenis.
TT in rs28379706, lower IQ.
GG in rs324640, 8 points higher IQ than individuals with 'AA' .
CC in rs1815739, Better performing muscles. Likely sprinter.
TT , No 'fat gene' variants in FTO's rs9939609.
TT in rs10427255, likely does not have photic sneeze reflex.
GG in SCN9A rs6746030 variation, no variants for increased pain sensitivity.
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer.
AG in rs1080066, larger brain volume. Rare .
Drug Responce
Risk of Heart Failure Due to Beta Blocker Medications is 1.000 times the average.
When treated with metoprolol
Relative to AA in rs1801252 & GG in rs1801253 Genotypes :
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : &
AA in CYP2C9's rs1057910, normal; no effect on warfarin metabolism
CC in CYP2C9's rs1799853, Good, no risk of altered warfarin metabolism or NSAID metabolism
GG in rs3745274, no increased risk when taking efavirenz for HIV treatment
AA in rs2279343, normal responce to efavirenz for HIV treatment.
AA in rs28399433, No Reduced CYP2A6 metabolism and no impaired nicotine metabolism - typical genotype
CC in CYP1A2's rs28399424, Good, normal CYP1A2 activity
GG in rs4986893, no CYP2C19*3 allele (Good)
TT in rs4363657, lower(typical) myopathy risk for statin users
AG in rs637644, average odds of hair loss from chemotherapy- risk allele is G. ⚠
GG in rs2273697, Adverse reaction less likely to carbamazepine in epileptic patients
CT in rs2298383, one allele for increased anxiety in response to caffeine. ⚠
CC in rs1467558, lower (normal) risk of liver toxicity from acetominophen/tylenol/APAP
TT in rs12476047. Lower than average odds of parkinson's symptoms when treated with antipsychotics
CC in rs5092, significantly less likely to gain weight if taking olanzapine.
CC in rs4765623, significantly more likely to gain weight if taking olanzapine. ⚠
GG in rs518147, significantly higher odds of weight gain if taking olanzapine. ⚠
CC in AKT1's rs2494732, greater odds of cannabis-associated psychosis. ⚠
GG in rs2241802, higher odds of methamphatamine induced psychosis. ⚠
CC in rs135745, higher susceptibility to methamphetamine induced psychosis. ⚠
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation.
AA in TYR's rs28940881 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
AA in TYR's rs28940878 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism.
CC in TYR's rs104894313, Not Carrier of an oculocutaneous Albinism Type 1B mutation.
CC in TYRP1's rs104894130, which means this individual lacks variants for Oculocutaneous albinism type 3, and is not albino.
CC in TYRP1's rs387907171, not a Carrier of melanesian blond hair variants.
Familiar Mediterranean Fever Panel
0 risk variants in rs104895094.
0 risk variants in rs61752717
0 risk variants in rs28940579.
0 risk variants in rs28940578.
0 risk variants in rs61732874.
0 risk variants in rs104895097.
0 risk variants in rs104895085
0 risk variants in rs104895157
0 risk variants in rs11466024
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
AA in rs17367504, common , average (higher) blood pressure.
CC in rs2274976, Good, lower odds of neural tube defects
GG in rs2066470, typical genotype.
Cancers Panel
Highest Odds of Epithelial Cancers: 13.158 %.
Intermediate (slightly higher) Odds of Epithelial Cancers: 39.474 %.
Lower (typical) Odds of Epithelial Cancers: 47.368 %.
Glioma
AA in EGFR's rs11979158, very slight increase in the odds of glioma.
TT in EGFR's rs2252586, higher odds of glioma
AA in rs498872, increase in the odds of glioma.
GG in rs4977756, 1.93x higher risk for glioma development
GG in rs6010620, 1.4x higher risk for glioma development; but this is the common allele. 1.4x higher risk for atopic dermatitis in Han Chinese
Prostate
CC in HOXB13's rs138213197, normal (lower) risk of prostate cancer in men
No rare variant for prostate cancer
CC in 8q24 rs16901979, no risk alleles for prostate cancer (Good)
TG in 8q24 rs6983267, 1.3x risk of prostate cancer. Risk allele is G
CC in 8q24 rs1447295, no risk alleles for prostate cancer (Good)
Breast - BRCA
0 risk variants in S1140G of BRCA1
2 risk variants in S1613G of BRCA1
1 risk variant in N372H of BRCA2.
TT in rs1801155, average (lower) risk of colon cancer
0 risk variants in S707P
Testicular - KITLG
AA in rs4474514, >3x increased testicular cancer risk for men
Other Cancers
AA in AURKA's rs2273535, slightly lower (normal) odds for various cancers
CC in rs798766, Lower (normal) risk of developing urinary bladder cancer.
GG in rs1800629, good, lower odds of lymphoma among a variety of other illnesses.
TNF Risk Variants for Lymphoma: 0 Out of 6 variants found in file in total
No risk variants found in file
Presence of Any risk variants are a concern
Thyroid Cancer
AA in rs1867277, 2x increased risk for thyroid cancer.
AA in rs965513, 3.1x increased thyroid cancer risk.
CC in rs116909374, typical(lower) odds of thyroid cancer
CC in rs2439302, lower odds of thyroid cancer
Leukemia Panel
AG in rs1800566, 1 NQO1*2 allele (1 risk variants for leukemia).
TT in rs4132601, common -> lower risk of leukemia.
TT in rs7089424, common/normal and lower risk of Leukemia.
AA in rs2239633, lower odds of leukemia (~0.7x).
GG in rs662463, common , lower odds of leukemia.
Rare diseases/traits Panel
No rare variant for prostate cancer
AA in F9 rs137852229, not a Carrier of a Hemophilia B mutation - 0 risk variants
CC in rs41280169, 0 risk variants for panic disorder (very common genotype)
GG in rs79919349, 0 risk variants for panic disorder (very common genotype).
CC in rs119478057, no predidposition to Hypercarotenemia and vitamin a deficiency
GG in rs28942100, not a Carrier of a alkaptonuria mutation - 0 risk variants
TT in rs121434622, no Fragile X syndrome
CC in rs199473058, no Brugada Syndrome
GG in rs121434528, 0 risk alleles for Thoracic aortic aneurysm and dissection
GG in rs74315329, not a carrier for Glaucoma (primary open-angle).
CC in rs28936694, no Primary open-angle glaucoma
CC in rs6445; no congenital adrenal hyperplasia
0 variants for Ehlers-Danlos syndrome; CC in rs28937869
Found 0 risk variants for Holoprosencephaly in GLI2. Very typical/common genotype
GG in rs34536443, typical (lower) odds of tuberculosis infection, common genotype
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
AA in rs660895, decreased risk of rheumatoid arthritis. Slightly decreased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
CC in rs7743761, Normal (lower) risk of Ankylosing Spondylitis.
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
GG in rs104894637 - not a carrier for Sanfilippo syndrome risk
CC in rs104894635, no risk variants for Sanfilippo syndrome
CC in rs1800546, normal.
TT in rs74315405, no Gerstmann–Straussler–Scheinker syndrome.
GG in rs11606250, most common , but higher risk for certain autoimmune diseases.
CC, 2 risk variants in rs2302009. 4.6x higher odds of eosinophilic esophagitis
Celiac Disease Panel
average, no HLA-DRB1*0301 alleles, normal risk of celiac disease and lupus.
2 risk variants in CCR3
No risk variants in IL18R1
AA in rs13119723, lower (normal) risk for celiac disease. 0 risk variants
No risk variants in R262W
Allergies Panel
GG in rs62623409, typical odds of allergic sensitivity
GG in rs2367563, lower odds of allergic skin reaction to nickel.
CC in rs17513503, lower odds of allergies; common
GT in rs7192, somewhat (1.7x) increased risk of developing a peanut allergy. Risk variant is T.
Androgen Receptor Gene (AR) Panel
CC in rs137852591, very typical ; no Androgen insensitivity.
GG in rs9332969, normal , no Reifenstein syndrome.
Crohn's Disease Panel
CC in NOD2's Arg702Trp. Typical (lower) risk for Crohn's disease.
GG in rs2066845, normal (lower) risk for Crohn's disease. Risk allele is C.
Canavan Syndrome Panel
GG in rs104894553, 0 risk variants.
0 risk variants in A305E.
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
0 protective variants in C927T (Bad), most typical genotype.
common (Good), no risk variants in rs2395029 (TT )
HLA Gene Panel
The HLA genes are located on chromosome 6 in humans and encode proteins called human leukocyte antigens (HLAs). These proteins play a vital role in immune responses by presenting antigens to immune cells, specifically T cells. There are two main classes of HLA proteins: class I and class II.
The HLA system plays a critical role in several medical contexts, including organ transplantation, where matching HLA types between donor and recipient is crucial to minimize the risk of rejection. Additionally, HLA genes are associated with susceptibility to certain autoimmune diseases, infectious diseases, and drug hypersensitivity reactions, making them important targets for medical research and personalized medicine.
Here is a list of conditions affected by, and predicted by this Panel: Rheumatoid arthritis, systemic lupus erythematosus (SLE), type 1 diabetes mellitus, multiple sclerosis (MS), Sjögren's syndrome, inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis, celiac disease, ankylosing spondylitis, systemic sclerosis, psoriasis, Graves' disease, Hashimoto's thyroiditis, Addison's disease, vitiligo, myasthenia gravis, primary biliary cholangitis, autoimmune hepatitis Susceptibility or severity of certain viral infections (e.g., HIV, hepatitis B and C), some bacterial infections (e.g., leprosy, tuberculosis) Food allergies (e.g., peanut allergy, milk allergy), Allergic rhinitis (hay fever), Atopic dermatitis (eczema), Asthma Allograft rejection, Preeclampsia, and Certain neurological disorders (e.g., narcolepsy)
Highest odds of Autoimmune Disease 6.667 %
Intermediate (Slightly higher) Odds of Autoimmune Disease 43.333 %
Lower Odds of Autoimmune Disease 50.000 %.
MTRR Gene Panel
AA in rs1801394, lower odds for meningomas and neural tube defects. 0 risk alleles for disorders of Cobalamin Metabolism
CC in rs10380, lower odds of pancratic cancer; 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AA in rs162036, no risk variants for spina bifida & Disorders of Intracellular Cobalamin Metabolism.
CC in rs2287780, no risk variants for Disorders of Intracellular Cobalamin Metabolism
TT in rs2303080, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
GG in rs1802059, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
CBS Panel
CC in CBS's rs234714, lowest Plasma homocysteine levels (highest impact snp)
TT in CBS's rs234709, decreased homocysteine levels (small impact)
Predisposed to higher levels of Plasma homocysteine + 0.02 µmol/L increase, CC in rs2851391
homocystinuria Panel
We found
No risk variants found in file!
and a total of 0 risk variants for homocystinuria in CBS gene out of 10 variants identified in your file in total.
Elevated homocysteine levels 15.385 %
Intermediate homocysteine levels 30.769 %
Lower homocysteine levels 53.846 %.
Muscular Dystrophy Myopathies
0 risk variants in rs121913574
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk variants in rs28937903
0 risk variants in rs28937904
0 risk alleles in rs2296949
Found : 0 risk variants for adrenoleukodystrophy out of 24 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 4
0 risk variants in OPN1MW out of 4
0 risk variants in OPN1SW out of 6
FTO Gene Panel
Higher Odds of Obesity 14.286 %.
Intermediate Odds of Obesity42.857 %.
Lower Odds of Obesity42.857 %.
No risk variants for obesity in rs9930506, lower risk of obesity
No fat gene variants in rs11642015, lower odds of obesity
GG in rs1121980, lower BMI, decrease in the risk of obesity
TT , No 'fat gene' variants in FTO's rs9939609.
Within PFKP Gene - also implicated in Obesity
AA in rs6602024, much higher BMI
Others also implicated in Obesity
AA in rs4994, typical genotype - lower odds of obesity.
CC in rs1799883, This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
CC in rs12465214 of ZNF804A, increased odds of Syncope. Odds ratio of ~1.1, this is the lowest pval (most statistically significant) snp for syncope risk
AA in rs1431318, around 7% increase in the risk of syncope.
Used 5 snps in the following prediction
Syncope risk is 0.985 times the average
Bio Traits Panel
CC in rs1544410, Decreased risk of low bone mineral density disorders
GG in CDH4's rs16985493, typical genotype associated with lower/average risk for migraine.
TT in rs185819, ~30mm shorter
CC in rs1042725, ~0.8cm taller height relative to TT genotype
AA in rs10946808, taller.
GG in rs1800795, more IL6, significantly associated with type-2 diabetes (odds ratio 1.51)
TT in rs2148710, higher predisposition to anger
Two copies of "farmer" CLTCL1 gene variant. has a selective advantage in processing carbohydrate-rich diets (presumably including those with lots of sugar)
CC in rs307377, common in complete genomics - no extraordinary tasting ability
AA in rs662799, normal (Lower odds of heart attack and obesity)
CC in rs27072, 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD
AA in rs6591536, less able to detect β-ionone (floral) fragrance
Age Related Macular Degeneration
GG in rs547154, no increased protection from Age-related maculopathy, most typical genotype.
CC in rs1061147, Reduced 0.34x risk of Age Related Macular Degeneration.
AA in rs11200638, ~10x increased risk of wet age related macular degeneration
TT in rs1061170; lower risk for AMD, generally longer live than (C) allele carriers
CC in rs380390, much higher odds of AMD
CC in rs3793917, lower (typical) odds for AMD
Cataracts Panel
GG in rs62621812, typical genotype, lower (typical) risk for cataracts.
AA in rs4814857,typical genotype, lower (0.96x) risk for cataracts
TT in rs8044853, ~0.7x reduced odds of cataracts
GG in rs1929494, slightly reduced (~0.93x) risk for cataracts.
CC in rs926937, higher(typical) risk of cataract
Vitamins and Levels
GG in rs2282679 of GC gene, typically lower levels of Vitamin D. ⚠
AA in rs7041, ex-smokers at 2x higher risk for chronic obstructive pulmonary disease ; supplement with Vitamin D - [1985.17-2233.51] nmol/L decrease of vit D levels ⚠
TG in rs12785878, likely lower levels of Vitamin D. ⚠
AA in rs10741657, tend to have higher vitamin D levels
CC in rs6544713, slightly lower LDL cholesterol
TT in rs10047474, increased blood pressure ⚠
GG in rs4961 (imputed through rs4963), lower blood pressure
AA in rs4895441, lower red blood cell count ⚠
AA in rs1063739, decreased protection of neurons against glutamate toxicity, decreased rate of glutamate degradation ⚠
CC in rs4654748, 1.45 ng/ml decrease in B6 levels ⚠
CC in rs33972313, typical (higher) levels of Vitamin C
Predisposed to lower levels of Vitamin A/Retinol, CC in rs780093 ⚠
GG in rs11057830, lower(typical) levels of Vitamin E.⚠
GG in rs6862909, typical genotype, higher - typical Vitamin K levels
CC in rs964184, typical (lower) levels of vitamin K ⚠
DVT Panel
CC in rs11121615, higher odds of varicose veins. Highest pval and beta snp for this trait
CC in rs6025, lower (normal) risk of deep vein thrombosis
AA in rs7654093, slightly lower odds of deep vein thrombosis
GG in rs7025486, lower odds of aneurysm and vascular disorders
Blood Group Panel
CC in rs635634, higher odds for all blood types besides A. 0.92 accuracy
CC in rs8176720, not blood type A or O. 0.77 accuracy
GG in rs7030248, Likely no Blood type B or AB. Accuracy 0.74
TT in rs493014, no blood type B or AB. Accuracy 0.75.
GG in rs687289, Likely not Blood type AB. Accuracy 0.91
TT in rs505922, Likely blood type O. 0.8 accuracy
TT in rs529565, Likely blood type O. 0.98 accuracy
TT in rs8176740, higher odds of B and O blood types
