GG in COMT's Val/Met variation, meaning Val/Val , or warrior , higher activity of the COMT enzyme and quicker breakdown of dopamine. Individuals with this have advantages in stress resilience but disadvantages in attention tasks.
CC in rs4633, higher expression levels of the COMT protein and protection from endometrial cancer, lower pain sensitivity - warrior
TT in COMT's rs4646312, slightly lower odds of schizophrenia
GG in COMT's rs6267, which is the typical for most humans and leads to slightly lower risk of Schizophrenia
GG in COMT's rs165599 variation, which typically results in higher risk of Schizophrenia and Bipolar disorder.
GG in rs3027452,higher level of MAOB enzyme - typical genotype. Tryptophan more effective for depression.
TT in MAOB's rs1799836; Higher odds of ADHD, Parkinson's, One study found lower odds of Schizophrenia
GG in MAOB's rs6324, typical (lower) ADHD risk, most common genotype
TT in MAOA's rs6323, leading to lower activity of the MAOA enzyme and slower breakdown of dopamine, thus higher dopamine levels and certain advantages in attention tasks.
GG in MAOA's rs1800659, higher odds of post-surgical pain.
AA in MAOA's rs979605, increased MAOA activity, warrior.
CC in MAOA's rs766117, higher odds of depression
Less D2 dopamine receptors 35.211 %.
Intermediate number of D2 dopamine receptors 35.211 %.
Higher number of D2 dopamine receptors 29.577 %.
GG, which means no derived No-Go Learner variants in DRD2's Pro319Pro variation, which means a higher number of D2 receptor sites in the brain, and a higher likelihood of schizophrenia
GG in rs6279 of DRD2, higher odds for Schizophrenia and less resistence to pain
GG in DRD2's rs6275 variation, meaning less Dopamine D2 receptors and decreased risk of Schizophrenia.
CC in DRD2's rs2514218, higher odds of Schizophrenia
GG genotype in rs4648317 of DRD2, which is the typical genotype for most humans, and leads to a slightly lower risk of Schizophrenia and nicotine dependence.
AA in Taq1 variation of DRD2, which is implicated in a greatly decreased number of Dopamine D2 receptor sites in the brain and an increased likelihood of Alcoholism, Parkinson's, ADHD, and various other illnesses. This is not a typical human .
TT in DRD2's rs12363125, higher odds of Cocaine dependence - Risk haplotype for migraine
AA in DRD2's rs6589377, higher (typical) odds of neuroticism, but lower odds for nicotine dependence.
CC in rs1076560 of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors and better memory performance.
GG in rs686 of Dopamine Receptor D1 gene, which is the typical and leads to lower likelyhood of autism.
TT in DRD1's rs4867798, part of a haplotype for reduced risk of schizophrenia according to 2014 study
AA in DRD1's rs265974, ~0.77x lower odds of substance use disorders.
GG in DRD3's rs167771 variation, a typical genotype for most humans, leading to lower odds of Autism
GG in DRD3's rs963468, some protection from schizophrenia (doesn't play a role in the polygenic risk score calculation).
CC in rs11246226 of DRD4, which is a typical human and leads to decreased risk of Schizophrenia.
No risk variants for mental retardation in DRD4's rs752306 (CC)
CC in DRD5's rs6283. Higher odds of ADHD; mechanism of action is not exactly known
Lower levels of 5-HT (Serotonin) 36.667 %.
Intermediate levels of 5-HT (Serotonin) 40.000 %.
Higher levels of 5-HT (Serotonin) 23.333 %.
TT in rs2129785, a typical for most humans. The implications of this is that this individual does not have long form 5-HTTLPR and does not have a decrease in the risk of depression.
CC in rs6311 of HTR2A, robustly increased risk of suicidal behavior and depression. 3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants
GG in rs6313 of HTR2A, lower odds for suicidal ideation.
GG in HTR2A's rs2070040, G allele is associated with lower resistance to stress, irritability, and agressive behavior.
TT in HTR2A's rs4142900, G allele is associated with higher antisocial behavior and impulsivity
GG in rs1545843, NOT associated with higher risk for major depression (risk allele is A)
AA in rs17144465, typical (lower) depression risk.
AA in ESRRG's rs2377360, lower odds of depression
TT in rs364477, reduced odds of unipolar depression
TT in rs9834970 of TRANK1, below average odds of Bipolar disorder and Schizophrenia
CC in DISC1 rs1411771, higher odds of bipolar and schizophrenia (does not play a role in polygenic risk scores)
GG in rs75459873, no risk variants for psychosis in MIR378F. Very typical genotype.
Homozygous major allele at ADCY2 gene. Associated with decreased bipolar risk.
AA in ADCY2's rs17826816, lower(typical) odds for bipolar disorder.
CC in rs267606861, common in clinvar, no tourette
AA in rs11074889, Much higher odds of ADHD
Results Mental Health - Autism Only
Higher Odds of Autism 35.484 %.
Intermediate Odds of Autism35.484 %.
Lower Odds of Autism29.032 %.
TT in rs4307059, 1.42x risk of Autism, worse cell adhesion in neurons.
TT in rs10513025, typical , normal (higher) risk of autism.
TT in rs7794745, slightly increased risk for autism. Risk allele is T.
CC in rs1804197, common genotype. Normal (lower) risk of autism.
AA in rs2217262, typical genotype. Average (higher) risk of autism.
GG in rs930707, typical (higher) Indoleacetate levels. Indoleacetate is a tryptophan derivative and lower levels of indoleacetate are linked with depressive symptoms.
CC in rs921451, lower tendency to smoke heavily if is a smoker.
TT in rs1451371, More likely to smoke heavily if is a smoker.
GG in rs2060762, More likely to smoke heavily if is a smoker.
Results For Lactose Persistence
GG in MCM6's rs4988235 variation, which means this individual does not carry the European lactose persistence mutation.
CC in MCM6's rs182549, This Individual does not have any derived variants for European lactose persistence.
AA in rs41380347, NOT carrier of the lactase persistence allele also known as "-13915*G", common in Arab populations
TT in rs2322659 of LCT, likely lactose intolerant
Higher Odds of Lactose Intolerance: 50.000 %.
Intermediate Odds of Lactose Intolerance: 47.500 %.
Lower Odds of Lactose Intolerance: 2.500 %.
Results for OXTR - The Empathy Gene
Lower Empathy 6.667 %.
Average Empathy 33.333 %.
Higher Empathy 60.000 %.
GG in OXTR's rs53576 variation, which means this individual has 2 variants for higher levels of empathy at this variation.
GG in rs237885, two 'empath' variants in OXTR.
AA in OXTR's rs7632287 variation, which means this individual has 2 variants for higher OXTR expression and increased empathy.
GG in OXTR's rs237897, two variants for higher levels of empathy in this OXTR variation. Most likely not East Asian.
Results for Diabetes
CC in rs6679677; normal(lower) risk for Rheumatoid Arthritis and Type 1 Diabetes
GG in rs12255372, decreased risk of Type 2 Diabetes.
AA in rs17696736, slighly lower odds of type 1 Diabetes
AA in rs35011184, much higher odds of Type 2 diabetes and obesity.
GG in rs2476601 variation, which leads to lower risk of various autoimmune disorders and type 1 diabetes.
GG in rs17388568, normal (lower) odds of Type 1 Diabetes.
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes.
GG in rs7754840, which means this individual has two variants for lower odds of type 2 diabetes.
TT in rs7903146, a associated with a great increase (precisely a 2 fold increase) in the risk of type 2 diabetes.
GG in rs4402960, leading to slight decrease in the risk of Type 2 Diabetes.
Results for Hemochromatosis
GG in HFE's Cys282Tyr variation, which means this individual is not a carrier for the C282Y hemochromatosis mutation.
CC in HFE's His63Asp, which means this individual does not have any H63D variants and most likely doesn't have hemochromatosis.
AA in HFE's S65C variation, which means that this individual does not carry any risk variants for hemochromatosis.
Results for Alzheimers
CC in rs429358, 2 risk alleles for Alzheimers in this APOE variation, 12 to 61 times higher odds of Alzheimers than average.
TT in rs3025786, which is a typical for most humans and leads to average (slightly increased) risk of Alzheimers.
GG in PLD3's rs145999145 variation, which means this individual has a lower risk of Alzheimers.
TT in rs669, which leads to slightly decreased risk of Alzheimers.
GG in TOMM40's rs2075650, significantly higher odds of Alzheimer's disease.
CC in rs63750847, no variants for reduced risk of Alzheimer's disease. Normal (Higher) odds of Alzheimers
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS. Lower (typical) odds for narcolepsy as well.
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
AA in rs4959039, 2 (common) risk variants for MS.
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
TT in rs602633, 2 risk variants for Coronary Heart Disease (Odds ratio = 1.11 for every T allele). Sort of uncommon.
AA in rs700651, normal (lower) risk of aneurysm
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
CC in rs1333040, lower odds of brain aneurysm and heart attack, risk allele is T.
AA in rs9298506, normal (higher) risk of aneurysm.
TT in rs6475606, increased risk for Coronary artery disease.
CC in rs10757272, Normal (lower) risk for Coronary artery disease.
CC in rs9315204, lower risk of aneurysm, common genotype.
AA in rs10757274, normal(lower) risk of heart disease.
AA in rs2383206, normal(lower) risk of heart disease.
AA in rs10757278, 0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm..
TT in rs1800787, likely has carotid arthery disease (6x risk).
AA in rs5082, Higher (normal) risk of heart disease.
AA in rs17576, Higher odds of heart attack, lower odds of lung cancer.
CC in rs3918242, lower (normal) odds of heart attack, risk allele is T.
Asthma + Epilepsy Panel
TT in rs7216389, 1.5x increased risk for Childhood Asthma.
GG in rs1695, 3.5x asthma risk in certain populations
CC in rs10030601, 1.58x higher odds of epilepsy
CC in rs10496964, typical (higher) odds of epilepsy
CC in rs7587026; decreased (typical) odds of epilepsy
AA in rs12059546, lower (typical) odds of epilepsy
GG in rs72823592, 1.3x odds of epilepsy
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness.
AA in rs7744813, which leads to a decrease in the risk of myopia.
AT, or heterozygous in rs524952, which means a slightly decreased risk of myopia.
CC in rs4803455, two alleles for increased Myopia risk.
GG in RBFOX1's rs17648524, two alleles that protect against myopia.
CC in rs3138142, higher odds of myopia.
Facial Morphology Panel
AA in rs6542787, 2 European EDAR alleles. Likely a European with European facial morphology
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
CC in rs892540, longer (typical) midface length
AA in PAX3s rs7559271, higher odds of protruding nasal bridge
CC in rs4648379, larger nose size.
Likely slightly lower nasolabial angle (nose drooping down) based on DCHS2 genotype
CC in rs938036, likely has mandibular third molar, lower odds of tooth agenesis (missing teeth)
TT in rs12651896, slightly thinner eyebrows
AA in rs7702108, slightly thicker eyebrows
Miscellaneous
(Don't voice this in video!!) CC in rs9332964, no micropenis.
(Don't voice this in video!!!) GG in SRD5A2's rs104893667 variation, which means this individual does not have micropenis.
TT in rs10784502, smaller cranium and lower IQ.
CC in rs28379706, higher IQ.
AA in rs324640, 8 points lower IQ than individuals with 'GG' .
CC in rs1815739, Better performing muscles. Likely sprinter.
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
TT in rs10427255, likely does not have photic sneeze reflex.
GG in SCN9A rs6746030 variation, no variants for increased pain sensitivity.
TT, no MYBPC2 mental retardation variants, likely healthy.
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer.
GG in rs1080066, much larger brain volume. Very rare
CC in rs6265, higher odds of obesity and major depressive disorder
Drug Responce
Risk of Heart Failure Due to Beta Blocker Medications is 1.863 times the average.
When treated with metoprolol
Relative to AA in rs1801252 & GG in rs1801253 Genotypes :
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : GG in rs1801252 &
CC in EGFR's rs2293347, among NSCLC patients, better Gefitinib response; common
AA in CYP2C9's rs1057910, normal; no effect on warfarin metabolism
CC in CYP2C9's rs1799853, Good, no risk of altered warfarin metabolism or NSAID metabolism
GG in rs3745274, no increased risk when taking efavirenz for HIV treatment
GG in rs2279343, Lower doses of efavirenz for treating HIV may be recommended. ⚠
AA in rs28399433, No Reduced CYP2A6 metabolism and no impaired nicotine metabolism - typical genotype
CC in CYP1A2's rs28399424, Good, normal CYP1A2 activity
CC in CYP1A2's rs12720461, Good, normal CYP1A2 activity
GG in rs4986893, no CYP2C19*3 allele (Good)
GG in rs4244285, normal in CYP2C19 (Good) no issues metabolizing antidepressants, mephenytoin, or Plavix
GG in CYP2D6's rs1065852, NOT carrier for CYP2D6 decreased or non-functioning variants (good)
TT in rs4363657, lower(typical) myopathy risk for statin users
GG in rs2273697, Adverse reaction less likely to carbamazepine in epileptic patients
CC in rs2298383, increased anxiety in response to caffeine. ⚠
AA in rs762551, Faster caffeine metabolism in smokers and heavy coffee consumers ⚠
CC in rs3892097, extensive CYP2D6 metabolizer
CC in rs1467558, lower (normal) risk of liver toxicity from acetominophen/tylenol/APAP
TT in rs10156191 of AOC1, decreased DOA activity, negative responce to NSAIDs. This is an uncommon genotype. ⚠
TT in rs12476047. Lower than average odds of parkinson's symptoms when treated with antipsychotics
CC in rs5092, significantly less likely to gain weight if taking olanzapine.
CC in rs4765623, significantly more likely to gain weight if taking olanzapine. ⚠
CC in rs3813929, higher odds of weight gain if taking olanzapine. ⚠
CC in rs518147, less weight gain if taking olanzapine.
GG in rs135745, lower susceptibility to methamphetamine induced psychosis.
AA in rs12591257, no protection from Methamphetamine induced psychosis ⚠
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation.
AA in TYR's rs28940881 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
AA in TYR's rs28940878 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism.
CC in TYR's rs104894313, Not Carrier of an oculocutaneous Albinism Type 1B mutation.
CC in TYRP1's rs104894130, which means this individual lacks variants for Oculocutaneous albinism type 3, and is not albino.
AA in rs987525, which leads to 6x increased risk for cleft lip.
CC in TYRP1's rs387907171, not a Carrier of melanesian blond hair variants.
Familiar Mediterranean Fever Panel
0 risk variants in rs104895094.
0 risk variants in rs11466023
0 risk variants in rs61752717
0 risk variants in rs28940579.
0 risk variants in rs28940578.
0 risk variants in rs61732874.
0 risk variants in rs104895083.
0 risk variants in rs104895097.
0 risk variants in rs104895085
0 risk variants in rs11466024
0 risk variants in rs11466026
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
GG in MTHFR's rs1801133, normal homocysteine levels, good . Slightly lower than average odds for a variety of illnesses from autism to coronary heart disease.
TT in MTHFR's rs1801131, most common genotype , lower odds of various health issues.
GG in rs17367504, very uncommon , lower blood pressure.
CC in rs2274976, Good, lower odds of neural tube defects
GG in rs2066470, typical genotype.
Cancers Panel
Highest Odds of Epithelial Cancers: 37.209 %.
Intermediate (slightly higher) Odds of Epithelial Cancers: 37.209 %.
Lower (typical) Odds of Epithelial Cancers: 25.581 %.
Glioma
TT in 8q24 rs4295627, lower odds of glioma development
GG in EGFR's rs11979158, some protection from glioma.
TT in EGFR's rs2252586, higher odds of glioma
GG in rs498872, slightly below average odds of glioma (normal).
AA in rs4977756, lower odds of glioma
GG in rs6010620, 1.4x higher risk for glioma development; but this is the common allele. 1.4x higher risk for atopic dermatitis in Han Chinese
Prostate
GG in rs4430796, slightly lower (0.8) odds of prostate cancer.
AA in rs1859962, decreased risk for prostate cancer.
No rare variant for prostate cancer
AA in 8q24 rs16901979, >1.5x increased risk for prostate cancer
GG in 8q24 rs6983267, 1.6x increased risk for prostate cancer; also other cancers
CC in 8q24 rs1447295, no risk alleles for prostate cancer (Good)
Breast - BRCA
0 risk variants in Q356R of BRCA1
0 risk variants in BRCA1's D693N.
0 risk variants in S1140G of BRCA1
2 risk variants in K1183R of BRCA1
0 risk variants in S1613G of BRCA1
0 risk variants in N289H of BRCA2.
0 risk variants in N372H of BRCA2
GG in rs1042522 of TP53. common genotype. Slightly shorter lifespan. Higher odds of various cancers.
TT in rs1801155, average (lower) risk of colon cancer
0 risk variants in S707P
Testicular - KITLG
AA in rs995030, 6 times Reduced risk of testicular cancer
TT in rs3782179; common, but increased risk of testicular cancer
GG in rs4474514, reduced testicular cancer risk for men
Other Cancers
AA in AURKA's rs2273535, slightly lower (normal) odds for various cancers
AA in Estrogen Receptor 1 Gene's -351A>G variation. Women have lower risk of Endometriosis but normal risk for Endometrial Cancer, and more cognitive impairment with age.
GG in EGFR rs763317, lower(typical) risk of lung cancer
TT in rs710521, 1.4x increased risk of developing bladder cancer.
CC in rs798766, Lower (normal) risk of developing urinary bladder cancer.
GG in rs1800629, good, lower odds of lymphoma among a variety of other illnesses.
TNF Risk Variants for Lymphoma: 0 Out of 6 variants found in file in total
No risk variants found in file
Presence of Any risk variants are a concern
Thyroid Cancer
GG in rs965513, normal(lower thyroid cancer risk).
CC in rs944289, lower thyroid cancer risk
CC in rs116909374, typical(lower) odds of thyroid cancer
CC in rs966423, Possible elevated thyroid cancer risk
CC in rs2439302, lower odds of thyroid cancer
Leukemia Panel
no NQO1*3 alleles, average odds of leukemia.
GG in rs1800566, 0 NQO1*2 alleles (0 risk variants for leukemia)
TT in rs4132601, common -> lower risk of leukemia.
TT in rs7089424, common/normal and lower risk of Leukemia.
GG in rs662463, common , lower odds of leukemia.
Rare diseases/traits Panel
GG in rs75801644, 0 risk variants for endometriosis.
No rare variant for prostate cancer
AA in F9 rs137852229, not a Carrier of a Hemophilia B mutation - 0 risk variants
TT in rs9540294, average (lower) odds of Recalcitrant atopic dermatitis
CC in rs41280169, 0 risk variants for panic disorder (very common genotype)
GG in rs79919349, 0 risk variants for panic disorder (very common genotype).
No predisposition to hemoglobin E disease, TT in rs2071348
CC in rs119478057, no predidposition to Hypercarotenemia and vitamin a deficiency
GG in rs387906725, no Lesch-nyhan syndrome.
GG in rs28942100, not a Carrier of a alkaptonuria mutation - 0 risk variants
TT in rs121434622, no Fragile X syndrome
CC in rs199473058, no Brugada Syndrome
GG in rs121434528, 0 risk alleles for Thoracic aortic aneurysm and dissection
GG in rs74315329, not a carrier for Glaucoma (primary open-angle).
AA in rs893818, ~10x higher odds of Exfoliation glaucoma.
CC in rs28936694, no Primary open-angle glaucoma
AA in rs16863657, lower odds of neural tube defects, typical genotype.
CC in rs6445; no congenital adrenal hyperplasia
GG in rs80338794, not a Finnish major Salla disease mutation carrier - 0 risk variants.
0 variants for Ehlers-Danlos syndrome; CC in rs28937869
Found 0 risk variants for Holoprosencephaly in GLI2. Very typical/common genotype
Typical genotype, no Holoprosencephaly-3 risk variants in SSH
GG in rs34536443, typical (lower) odds of tuberculosis infection, common genotype
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
GG in rs10033464, 0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke.
AA in rs660895, decreased risk of rheumatoid arthritis. Slightly decreased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
CC in rs7743761, Normal (lower) risk of Ankylosing Spondylitis.
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
CC in rs4794067; 2.1x risk for Aspirin Induced Asthma. But possibly lower risk of lupus and intractable Graves' disease.
TT in rs10156191 of AOC1, decreased DOA activity, negative responce to NSAIDs. This is an uncommon genotype. ⚠
GG in rs104894637 - not a carrier for Sanfilippo syndrome risk
CC in rs104894635, no risk variants for Sanfilippo syndrome
No von Gierke's disease. CC in Arg83Cys of glucose-6-phosphatase G6PC gene.
AT, or heterozygous in rs12150220, slightly increased risk for several autoimmune diseases including Addison's disease.
CC in rs1800546, normal.
TT in rs74315405, no Gerstmann–Straussler–Scheinker syndrome.
AA in rs3764147, 0 risk variants for leprosy.
GG in rs11606250, most common , but higher risk for certain autoimmune diseases.
Celiac Disease Panel
No risk variants in CCR3
No risk variants in IL18R1
No risk variants in R262W
Allergies Panel
AA in rs2367563, nickel likely causes an allergic skin reaction.
TT in rs2155219, 2 alleles for higher odds of allergies. Odds Ratio for every T allele = 1.18
CC in rs17513503, lower odds of allergies; common
GG in rs7192, lower risk of developing a peanut allergy.
TT in rs9275596, lower risk of peanut allergy. Risk allele is C.
Androgen Receptor Gene (AR) Panel
GG in rs6152, typical (higher) odds of baldness.
CC in rs137852591, very typical ; no Androgen insensitivity.
GG in rs9332969, normal , no Reifenstein syndrome.
GG in rs9332971, normal , no Reifenstein syndrome.
Crohn's Disease Panel
GG in rs2066845, normal (lower) risk for Crohn's disease. Risk allele is C.
Canavan Syndrome Panel
AA in rs63751297, 0 risk variants.
0 risk variants in Y231X.
0 risk variants in A305E.
0 risk variants in E285A.
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
0 protective variants in C927T (Bad), most typical genotype.
0 protective variants in HLA-C's rs9264942 (Bad), typical genotype.
AA in rs2572886, 2 risk variants for increased susceptibility to AIDs and higher HIV viral load (Bad, very uncommon).
HLA Gene Panel
The HLA genes are located on chromosome 6 in humans and encode proteins called human leukocyte antigens (HLAs). These proteins play a vital role in immune responses by presenting antigens to immune cells, specifically T cells. There are two main classes of HLA proteins: class I and class II.
The HLA system plays a critical role in several medical contexts, including organ transplantation, where matching HLA types between donor and recipient is crucial to minimize the risk of rejection. Additionally, HLA genes are associated with susceptibility to certain autoimmune diseases, infectious diseases, and drug hypersensitivity reactions, making them important targets for medical research and personalized medicine.
Here is a list of conditions affected by, and predicted by this Panel: Rheumatoid arthritis, systemic lupus erythematosus (SLE), type 1 diabetes mellitus, multiple sclerosis (MS), Sjögren's syndrome, inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis, celiac disease, ankylosing spondylitis, systemic sclerosis, psoriasis, Graves' disease, Hashimoto's thyroiditis, Addison's disease, vitiligo, myasthenia gravis, primary biliary cholangitis, autoimmune hepatitis Susceptibility or severity of certain viral infections (e.g., HIV, hepatitis B and C), some bacterial infections (e.g., leprosy, tuberculosis) Food allergies (e.g., peanut allergy, milk allergy), Allergic rhinitis (hay fever), Atopic dermatitis (eczema), Asthma Allograft rejection, Preeclampsia, and Certain neurological disorders (e.g., narcolepsy)
Highest odds of Autoimmune Disease 11.111 %
Intermediate (Slightly higher) Odds of Autoimmune Disease 39.683 %
Lower Odds of Autoimmune Disease 49.206 %.
MTRR Gene Panel
AA in rs1801394, lower odds for meningomas and neural tube defects. 0 risk alleles for disorders of Cobalamin Metabolism
CC in rs10380, lower odds of pancratic cancer; 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AA in rs162036, no risk variants for spina bifida & Disorders of Intracellular Cobalamin Metabolism.
CC in rs2287780, no risk variants for Disorders of Intracellular Cobalamin Metabolism
TT in rs2303080, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
GG in rs1802059, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
CBS Panel
TT in CBS's rs234709, decreased homocysteine levels (small impact)
Predisposed to higher levels of Plasma homocysteine + 0.02 µmol/L increase, CC in rs2851391
homocystinuria Panel
We found
No risk variants found in file!
and a total of 0 risk variants for homocystinuria in CBS gene out of 22 variants identified in your file in total.
Elevated homocysteine levels 9.524 %
Intermediate homocysteine levels 42.857 %
Lower homocysteine levels 47.619 %.
Muscular Dystrophy Myopathies
0 risk variants in rs121913574
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk variants in rs28928901
0 risk alleles in rs2296949
0 risk variants in rs193922094
Found : 0 risk variants for adrenoleukodystrophy out of 42 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 4
0 risk variants in OPN1MW out of 8
2 risk variants in OPN1SW out of 8
FTO Gene Panel
Higher Odds of Obesity 32.500 %.
Intermediate Odds of Obesity42.500 %.
Lower Odds of Obesity25.000 %.
Homozygous for 'fat gene' variants in rs9930506, higher risk of obesity
No fat gene variants in rs1421085, lower odds of obesity
GG in rs9937053, lower BMI
No fat gene variants in rs11642015, lower odds of obesity
AA in rs1121980, much higher BMI. Moderate increase (2.76x) in risk for obesity
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
GG in rs9928094, highest odds of extreme obesity
Within PFKP Gene - also implicated in Obesity
Others also implicated in Obesity
GG in rs4994, highest odds of obesity. Very uncommon genotype.
CC in rs1799883, This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.
TT in rs6232, lower risk of obesity and insulin sensitivity
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
CC in rs12465214 of ZNF804A, increased odds of Syncope. Odds ratio of ~1.1, this is the lowest pval (most statistically significant) snp for syncope risk
GG in rs1431318, ~7% decreased odds of syncope.
Used 7 snps in the following prediction
Syncope risk is 0.882 times the average
Bio Traits Panel
AA in MTR's rs1805087, decreased MTR activity and increased homocysteine levels (doesn't contribute to homocysteine panel score)
CC in rs174547, lower resting heart rate, lower omega-6 and omega-3 levels
ACE I/I genotype, decreased ACE activity, increased odds for hypertension and a range of other issues.
CC in rs1544410, Decreased risk of low bone mineral density disorders
GG in rs1051730, Smokes normal (lower) number of cigarettes if a smoker, reduced odds of lung cancer.
rs5443 (CC) lower risk of hypertension and obesity, lower responce to viagra, less weight gain when treated with clozapine
CC in rs11777116, typical (lower) odds for migraine
TT in rs1042725, ~0.8cm shorter height relative to CC genotype
CC in rs6060369, ~0.88cm taller height relative to TT genotype
AA in rs10946808, taller.
GG in rs1800795, more IL6, significantly associated with type-2 diabetes (odds ratio 1.51)
AA in rs1380703, longer (typical) sleep duration
GG in rs66800491, lower (typical) odds of motion sickness (This is the variation with highest impact for motion sickness)
TT in rs2148710, higher predisposition to anger
Wet earwax. Normal (smellier) body odour. Normal colostrum. Typical for non-East Asians. CC in rs17822931
Two copies of "hunter-gatherer" CLTCL1 gene variant. Reduced ability to process carbs and sugars.
CC in rs307377, common in complete genomics - no extraordinary tasting ability
AA in rs662799, normal (Lower odds of heart attack and obesity)
GG in rs4481887, least likely to be able to smell asparagus metabolites in urine
GG in rs6591536, more able to detect β-ionone (floral) fragrance
GG in rs11800854, higher (typical) odds of periodontitis
Age Related Macular Degeneration
GG in rs547154, no increased protection from Age-related maculopathy, most typical genotype.
AA in rs1061147, 2.76x increased risk for Age Related Macular Degeneration.
TT in rs1061170; lower risk for AMD, generally longer live than (C) allele carriers
CC in rs380390, much higher odds of AMD
CC in rs3793917, lower (typical) odds for AMD
AA in rs800292, decreased odds of Age-related macular degeneration (MTAG)
Cataracts Panel
GG in rs62621812, typical genotype, lower (typical) risk for cataracts.
AA in rs4814857,typical genotype, lower (0.96x) risk for cataracts
TT in rs8044853, ~0.7x reduced odds of cataracts
GG in rs1929494, slightly reduced (~0.93x) risk for cataracts.
TT in rs926937, two alleles protecting from cataract, 0.73x risk
Vitamins and Levels
TT in rs2282679 of GC gene, normal levels of Vitamin D.
AA in rs7041, ex-smokers at 2x higher risk for chronic obstructive pulmonary disease ; supplement with Vitamin D - [1985.17-2233.51] nmol/L decrease of vit D levels ⚠
GG in rs12785878, higher levels of Vitamin D.
GG in rs10741657, tend to have lower vitamin D levels ⚠
TT in rs7129781, decreased odds of Vitamin D insufficiency
CC in rs6544713, slightly lower LDL cholesterol
GG in rs6756629, associated with increased LDL levels, decreased HDL cholesterol levels, and increased triglyceride levels. ⚠
CC in rs560887, slightly higher blood sugar ⚠
GG in rs4961 (imputed through rs4963), lower blood pressure
AA in rs4895441, lower red blood cell count ⚠
TT in rs140522, higher red blood cell count
AA in rs1063739, decreased protection of neurons against glutamate toxicity, decreased rate of glutamate degradation ⚠
GG in rs602662, Lower vitamin B12 levels. 49.77 pg/ml decrease in B12 levels per G allele relative to AA genotype ⚠
CC in rs34324219, higher (Typical) vitamin B12 levels.
CC in rs4654748, 1.45 ng/ml decrease in B6 levels ⚠
Predisposed to lower levels of Vitamin A/Retinol, CC in rs780093 ⚠
GG in rs11057830, lower(typical) levels of Vitamin E.⚠
CC in rs964184, typical (lower) levels of vitamin K ⚠
DVT Panel
CC in rs11121615, higher odds of varicose veins. Highest pval and beta snp for this trait
CC in rs6025, lower (normal) risk of deep vein thrombosis
GG in rs1799963, lower risk of deep vein thrombosis
GG in rs113092656, lower risk of deep vein thrombosis
GG in rs7025486, lower odds of aneurysm and vascular disorders
Blood Group Panel
CC in rs635634, higher odds for all blood types besides A. 0.92 accuracy
CC in rs8176720, not blood type A or O. 0.77 accuracy
GG in rs7030248, Likely no Blood type B or AB. Accuracy 0.74
GG in rs493014, likely blood type B or AB. Accuracy 0.75.
GG in rs687289, Likely not Blood type AB. Accuracy 0.91
TT in rs8176746, probably blood type AB. Accuracy 0.75.
TT in rs505922, Likely blood type O. 0.8 accuracy
TT in rs529565, Likely blood type O. 0.98 accuracy
AA in rs8176740, slightly lower odds of B and O blood types
